2-(3-Isobutyl-2-methylsulfanyl-3H-imidazol-4-yl)-benzoic acid methyl ester

Base Information

Chemical Name:2-(3-Isobutyl-2-methylsulfanyl-3H-imidazol-4-yl)-benzoic acid methyl ester
CAS No.:177212-74-7
Molecular Formula:C₁₆H₂₀N₂O₂S
Molecular Weight:304.413
Hs Code.:

Synonyms:2-(3-Isobutyl-2-methylsulfanyl-3H-imidazol-4-yl)-benzoic acid methyl ester

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Chemical Property of 2-(3-Isobutyl-2-methylsulfanyl-3H-imidazol-4-yl)-benzoic acid methyl ester

Chemical Property:

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Technology Process of 2-(3-Isobutyl-2-methylsulfanyl-3H-imidazol-4-yl)-benzoic acid methyl ester

There total 1 articles about 2-(3-Isobutyl-2-methylsulfanyl-3H-imidazol-4-yl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 610-94-6
2-bromobenzoic acid methyl ester

: 1-Isobutyl-2-methylsulfanyl-5-tributylstannanyl-1H-imidazole

: 177212-74-7
2-(3-Isobutyl-2-methylsulfanyl-3H-imidazol-4-yl)-benzoic acid methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium chloride; potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 2h;
DOI:10.1248/cpb.44.709

Reference yield:

: 177212-74-7
2-(3-Isobutyl-2-methylsulfanyl-3H-imidazol-4-yl)-benzoic acid methyl ester

: 99011-02-6
imiqimod

Guidance literature:: Multi-step reaction with 6 steps

1: 10percent aq. NaOH / dioxane / 12 h / Heating

2: Et₃N, DPPA / benzene / 1 h / 50 °C

3: 1,2-dichloro-benzene / 1 h / Heating

4: 88 percent / POCl₃ / 1 h / Heating

5: 93 percent / 28percent NH₄OH / methanol / 48 h / 150 °C

6: 80 percent / sodium bis(2-methoxyethoxy)aluminium hydride / toluene / 0.5 h / Heating

With ammonium hydroxide; sodium hydroxide; diphenyl-phosphinic acid; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; trichlorophosphate; In 1,4-dioxane; methanol; 1,2-dichloro-benzene; toluene; benzene;
DOI:10.1248/cpb.44.709