formic acid 4-oxo-1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-azetidin-2-yl ester

Base Information

• Chemical Name: formic acid 4-oxo-1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-azetidin-2-yl ester
• CAS No.: 218461-45-1
• Molecular Formula: C₁₉H₂₇NO₇
• Molecular Weight: 381.426
• Mol file: 218461-45-1.mol

Synonyms:formic acid 4-oxo-1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-azetidin-2-yl ester

Chemical Property of formic acid 4-oxo-1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-azetidin-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of formic acid 4-oxo-1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-azetidin-2-yl ester

There total 4 articles about formic acid 4-oxo-1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-azetidin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-4-vinyloxy-azetidin-2-one (218461-35-9) → formic acid 4-oxo-1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-azetidin-2-yl ester (218461-45-1)

Guidance literature:

With dimethylsulfide; N-ethyl-1-[{4-(phenylazo)-phenyl}-azo]-2-naphthalenylamine; ozone; In dichloromethane; at -78 ℃;

DOI:10.1016/S0040-4039(98)01841-3

Reference yield:

3,5-dimethyl-2,4,6-trimethoxybenzyl chloride (95467-63-3) → formic acid 4-oxo-1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-azetidin-2-yl ester (218461-45-1)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / dimethylformamide

2: 2,6-lutidine / CH₂Cl₂

3: Bu₄NHSO₄, butyllithium / -78 °C

4: O₃, dimethyl sulfide, Sudan red 7B / CH₂Cl₂ / -78 °C

With 2,6-dimethylpyridine; n-butyllithium; dimethylsulfide; N-ethyl-1-[{4-(phenylazo)-phenyl}-azo]-2-naphthalenylamine; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; ozone; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(98)01841-3

Reference yield:

3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propan-1-ol (218461-31-5) → formic acid 4-oxo-1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-azetidin-2-yl ester (218461-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,6-lutidine / CH₂Cl₂

2: Bu₄NHSO₄, butyllithium / -78 °C

3: O₃, dimethyl sulfide, Sudan red 7B / CH₂Cl₂ / -78 °C

With 2,6-dimethylpyridine; n-butyllithium; dimethylsulfide; N-ethyl-1-[{4-(phenylazo)-phenyl}-azo]-2-naphthalenylamine; tetra(n-butyl)ammonium hydrogensulfate; ozone; In dichloromethane;

DOI:10.1016/S0040-4039(98)01841-3

upstream raw materials:

1-[3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl]-4-vinyloxy-azetidin-2-one

3,5-dimethyl-2,4,6-trimethoxybenzyl chloride

3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propan-1-ol

trifluoro-methanesulfonic acid 3-(2,4,6-trimethoxy-3,5-dimethyl-benzyloxy)-propyl ester