{2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol

Base Information

• Chemical Name: {2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol
• CAS No.: 896420-67-0
• Molecular Formula: C₄₂H₅₁N₅O₂
• Molecular Weight: 657.899
• Mol file: 896420-67-0.mol

Synonyms:{2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol

Chemical Property of {2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol

There total 5 articles about {2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4-di-tertbutyl-6-chloromethylphenol (10193-84-7) + 2-{[bis(2-pyridinylmethyl)amino]methyl}-4-methyl-6-{[(2-pyridinylmethyl)amino]methyl}phenol (585527-36-2) → {2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol (896420-67-0)

Guidance literature:

In dichloromethane; triethylamine; at 20 ℃; for 24h;

DOI:10.1107/S0108270105039910

Reference yield: 67.0%

2-{[(3,5-di-tert-butyl-2-hydroxybenzyl)(pyrid-2-ylmethyl)amino]methyl}-6-(hydroxymethyl)-4-methylphenol (952407-78-2) + bis[(2-pyridyl)methyl]amine (1539-42-0) → {2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol (896420-67-0)

Guidance literature:

2-{[(3,5-di-tert-butyl-2-hydroxybenzyl)(pyrid-2-ylmethyl)amino]methyl}-6-(hydroxymethyl)-4-methylphenol; With thionyl chloride; In dichloromethane; at 20 ℃; for 2.5h;

bis[(2-pyridyl)methyl]amine; With triethylamine; In dichloromethane; Heating;

DOI:10.1002/ejic.200600676

Reference yield:

2-{[(3,5-di-tert-butyl-2-hydroxybenzyl)(pyrid-2-ylmethyl)amino]methyl}-6-formyl-4-methylphenol (952407-76-0) → {2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl}-4-methylphenol (896420-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 97 percent / NaBH₄ / methanol / 20 °C

2.1: SOCl₂ / CH₂Cl₂ / 2.5 h / 20 °C

2.2: 67 percent / Et₃N / CH₂Cl₂ / Heating

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;

DOI:10.1002/ejic.200600676

upstream raw materials:

2,4-di-tertbutyl-6-chloromethylphenol

2-{[bis(2-pyridinylmethyl)amino]methyl}-4-methyl-6-{[(2-pyridinylmethyl)amino]methyl}phenol

2-{[(3,5-di-tert-butyl-2-hydroxybenzyl)(pyrid-2-ylmethyl)amino]methyl}-6-(hydroxymethyl)-4-methylphenol

bis[(2-pyridyl)methyl]amine

Downstream raw materials:

dicopper(II)(μ-methoxy)[[2-[N,N-bis(2-pyridylmethyl)aminomethyl]-6-[N',N'-(3,5-di-tert-butylbenzyl-2-hydroxy)(2-pyridylmethyl)]aminomethyl]-4-methylphenoxy](tetraphenylboride)