(3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

Base Information

Chemical Name:(3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester
CAS No.:910046-73-0
Molecular Formula:C₂₆H₄₄O₄SSi
Molecular Weight:480.784
Hs Code.:

Synonyms:(3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

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Chemical Property of (3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

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Technology Process of (3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

There total 1 articles about (3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910046-60-5
(3R,5S)-3-hydroxy-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

: 69739-34-0
t-butyldimethylsiyl triflate

: 910046-73-0
(3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/ol061173h

Reference yield:

: 910046-73-0
(3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

: 910046-61-6
3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-7-oxo-heptanethioic acid S-tert-butyl ester

Guidance literature:: (3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester; With ozone; In dichloromethane; at -78 ℃; for 0.00833333h;

With triphenylphosphine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol061173h

Reference yield:

: 910046-73-0
(3R,5S)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)oct-7-enethioic acid S-tert-butyl ester

: 3,11-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-5-(4-methoxy-benzyloxy)-8,8-dimethyl-9-methylene-tetradec-13-enethioic acid S-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: O₃ / CH₂Cl₂ / 0.01 h / -78 °C

1.2: PPh₃ / CH₂Cl₂ / 1 h / 20 °C

2.1: Me₂AlCl / CH₂Cl₂ / -78 °C

With dimethylaluminum chloride; ozone; In dichloromethane;
DOI:10.1021/ol061173h