6-amino-4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-7-ethoxy-quinoline-3-carbonitrile

Base Information

Chemical Name:6-amino-4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-7-ethoxy-quinoline-3-carbonitrile
CAS No.:848133-86-8
Molecular Formula:C₂₅H₂₀Cl₂N₄O₂
Molecular Weight:479.365
Hs Code.:

Synonyms:6-amino-4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-7-ethoxy-quinoline-3-carbonitrile

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Chemical Property of 6-amino-4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-7-ethoxy-quinoline-3-carbonitrile

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Technology Process of 6-amino-4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-7-ethoxy-quinoline-3-carbonitrile

There total 8 articles about 6-amino-4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-7-ethoxy-quinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

: 848133-86-8
6-amino-4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-7-ethoxy-quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine hydrochloride / 2-methoxy-ethanol / Heating

2: aq. HCl / Heating

With hydrogenchloride; pyridine hydrochloride; In 2-methoxy-ethanol;
DOI:10.1021/jm040159c

Reference yield:

: 25351-89-7
N-(2-hydroxy-4-nitrophenyl)acetamide

: 848133-86-8
6-amino-4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-7-ethoxy-quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / K₂CO₃ / dimethylformamide / 60 °C

2: H₂ / Pd/C / tetrahydrofuran / 3 h / 28 - 30 °C / 2585.74 Torr

3: 524 g / toluene / 16 h / 90 °C

4: 42 percent / various solvent(s) / 20 h / 250 - 255 °C

5: 65 percent / POCl₃ / bis-(2-methoxy-ethyl) ether / 0.75 h / 100 - 102 °C

6: pyridine hydrochloride / 2-methoxy-ethanol / Heating

7: aq. HCl / Heating

With hydrogenchloride; hydrogen; pyridine hydrochloride; potassium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 2-methoxy-ethanol; diethylene glycol dimethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm040159c

Reference yield:

: 116496-76-5
4-acetamido-3-ethoxynitrobenzene

: 848133-86-8
6-amino-4-[3-chloro-4-(2-chloro-benzyloxy)-phenylamino]-7-ethoxy-quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd/C / tetrahydrofuran / 3 h / 28 - 30 °C / 2585.74 Torr

2: 524 g / toluene / 16 h / 90 °C

3: 42 percent / various solvent(s) / 20 h / 250 - 255 °C

4: 65 percent / POCl₃ / bis-(2-methoxy-ethyl) ether / 0.75 h / 100 - 102 °C

5: pyridine hydrochloride / 2-methoxy-ethanol / Heating

6: aq. HCl / Heating

With hydrogenchloride; hydrogen; pyridine hydrochloride; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 2-methoxy-ethanol; diethylene glycol dimethyl ether; toluene;
DOI:10.1021/jm040159c