tetraethyl 2,2'-[2,5-thienylbis(aminomethylidene-2-iminophenylene)]dimalonate

Base Information

• Chemical Name: tetraethyl 2,2'-[2,5-thienylbis(aminomethylidene-2-iminophenylene)]dimalonate
• CAS No.: 1338598-69-8
• Molecular Formula: C₃₄H₃₆N₄O₈S
• Molecular Weight: 660.748
• Mol file: 1338598-69-8.mol

Synonyms:tetraethyl 2,2'-[2,5-thienylbis(aminomethylidene-2-iminophenylene)]dimalonate

Chemical Property of tetraethyl 2,2'-[2,5-thienylbis(aminomethylidene-2-iminophenylene)]dimalonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tetraethyl 2,2'-[2,5-thienylbis(aminomethylidene-2-iminophenylene)]dimalonate

There total 3 articles about tetraethyl 2,2'-[2,5-thienylbis(aminomethylidene-2-iminophenylene)]dimalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,5-thiophenedicarboxaldehyde (932-95-6) + 2-[(2-aminophenylamino)methylene]malonic acid diethyl ester (14525-98-5) → tetraethyl 2,2'-[2,5-thienylbis(aminomethylidene-2-iminophenylene)]dimalonate (1338598-69-8)

Guidance literature:

With acetic acid; In benzene; for 15h; regioselective reaction;

DOI:10.1007/s10593-011-0798-9

Reference yield:

diethyl 2-ethoxymethylenemalonate (87-13-8) → tetraethyl 2,2'-[2,5-thienylbis(aminomethylidene-2-iminophenylene)]dimalonate (1338598-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 1 h / 20 °C

2: acetic acid / benzene / 15 h

With acetic acid; In diethyl ether; benzene;

DOI:10.1007/s10593-011-0798-9

Reference yield:

1,2-diamino-benzene (95-54-5) → tetraethyl 2,2'-[2,5-thienylbis(aminomethylidene-2-iminophenylene)]dimalonate (1338598-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 1 h / 20 °C

2: acetic acid / benzene / 15 h

With acetic acid; In diethyl ether; benzene;

DOI:10.1007/s10593-011-0798-9

upstream raw materials:

2,5-thiophenedicarboxaldehyde

2-[(2-aminophenylamino)methylene]malonic acid diethyl ester

1,2-diamino-benzene

diethyl 2-ethoxymethylenemalonate

Refernces

• 1、 Kudyakova,Burgart,Saloutin. "Heterocyclic dialdehydes: Linkers in the synthesis of macroacyclic ligands". supporting information; experimental part. p. 558 - 563. Retrieved 2012/01/13.