4H-1,3-Benzodioxin-7-carboxaldehyde,2,2-dimethyl-(9CI)

Base Information

• Chemical Name: 4H-1,3-Benzodioxin-7-carboxaldehyde,2,2-dimethyl-(9CI)
• CAS No.: 71780-43-3
• Molecular Formula: C11H12 O3
• Molecular Weight: 192.21
• Hs Code.: 2932999099
• Mol file: 71780-43-3.mol

Synonyms:2,2-Dimethyl-4H-benzo[1,3]dioxine-7-carboxaldehyde

Chemical Property of 4H-1,3-Benzodioxin-7-carboxaldehyde,2,2-dimethyl-(9CI)

Chemical Property:

• PSA: 35.53000
• LogP: 2.14420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-1,3-Benzodioxin-7-carboxaldehyde,2,2-dimethyl-(9CI)

There total 6 articles about 4H-1,3-Benzodioxin-7-carboxaldehyde,2,2-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ 3-Hydroxy-4-hydroxymethyl-3,4-O-isopropylidenbenzaldehyd (71780-43-3)

Guidance literature:

Reference yield: 83.0%

3-Hydroxy-4-hydroxymethyl-3,4-O-isopropylidenbenzylalkohol (71780-42-2) → 3-Hydroxy-4-hydroxymethyl-3,4-O-isopropylidenbenzaldehyd (71780-43-3)

Guidance literature:

With aluminum oxide; pyridinium chlorochromate; In toluene; for 2h;

Reference yield:

dimethyl aminoterephthalate (5372-81-6) → 3-Hydroxy-4-hydroxymethyl-3,4-O-isopropylidenbenzaldehyd (71780-43-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) 2N H₂SO₄, NaNO₂, 2.) H₂O / 1.) 0 deg C, 2.) heating

2: 88 percent / pyridine / 24 h

3: 61 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: 58 percent / p-TosOH / toluene / 0.75 h

5: 83 percent / pyridinium chlorochromate, Al₂O₃ / toluene / 2 h

With pyridine; aluminum oxide; lithium aluminium tetrahydride; sulfuric acid; water; pyridinium chlorochromate; sodium nitrite; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

upstream raw materials:

3-Hydroxy-4-hydroxymethyl-3,4-O-isopropylidenbenzylalkohol

dimethyl aminoterephthalate

dimethyl hydroxyterephthalate

2-Acetoxyterephthalsaeure-dimethylester

Refernces

• 1、 Weinges, Klaus,Reinel, Ute,Maurer, Wolfgang,Gaessler, Norbert. "Nonproteinogenic Amino Acids, IV. - EPC Synthesis of L-(+)-Forphenicine". . p. 833 - 838. Retrieved 2007/10/02.