9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine

Base Information

Chemical Name:9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine
CAS No.:630105-33-8
Molecular Formula:C₂₁H₂₀ClN₇O₅
Molecular Weight:485.887
Hs Code.:

Synonyms:9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine

Suppliers and Price of 9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine

There total 6 articles about 9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 522607-98-3
1,2-di-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-D-ribofuranose

: 630105-33-8
9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 83 ℃; for 2h;
DOI:10.1021/jm0300431

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 630105-33-8
9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine

Guidance literature:: Multi-step reaction with 4 steps

1: 2.2 g / pyridine / 2 h / 20 °C

2: aq. AcOH / 48 h / 60 °C

3: 1.42 g / pyridine / 3 h / 20 °C

4: 81 percent / (CH₃)3SiOSO₂CF₃ / 1,2-dichloro-ethane / 2 h / 83 °C

With pyridine; trimethylsilyl trifluoromethanesulfonate; acetic acid; In 1,2-dichloro-ethane; 4: Vorbrueggen-type coupling;
DOI:10.1021/jm0300431

Reference yield:

: 146035-68-9
[(3aR,5S,6R,6aR)-6-(azidomethyl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methoxy-tert-butyl-dimethylsilane

: 630105-33-8
9-(2-O-acetyl-3-C-azidomethyl-3-deoxy-5-O-toluoyl-β-D-ribofuranose)-6-chloropurine

Guidance literature:: Multi-step reaction with 5 steps

1: TBAF / tetrahydrofuran / 3 h / 20 °C

2: 2.2 g / pyridine / 2 h / 20 °C

3: aq. AcOH / 48 h / 60 °C

4: 1.42 g / pyridine / 3 h / 20 °C

5: 81 percent / (CH₃)3SiOSO₂CF₃ / 1,2-dichloro-ethane / 2 h / 83 °C

With pyridine; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; 5: Vorbrueggen-type coupling;
DOI:10.1021/jm0300431