di-tert-butyl [5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl phosphate

Base Information

Chemical Name:di-tert-butyl [5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl phosphate
CAS No.:1428929-72-9
Molecular Formula:C₃₆H₄₂F₃N₄O₆P
Molecular Weight:714.722
Hs Code.:

Synonyms:di-tert-butyl [5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl phosphate

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Chemical Property of di-tert-butyl [5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl phosphate

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Technology Process of di-tert-butyl [5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl phosphate

There total 1 articles about di-tert-butyl [5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1428927-03-0,1428949-59-0,1428949-60-3
N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

: 229625-50-7
di-tert-butyl chloromethyl phosphate

: 1428929-72-9
di-tert-butyl [5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl phosphate

Guidance literature:: N-[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.333333h;

di-tert-butyl chloromethyl phosphate; In N,N-dimethyl-formamide; mineral oil; for 1h;

Reference yield: 24.0%

: 1428929-72-9
di-tert-butyl [5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl phosphate

: 1428929-73-0,1429013-00-2,1429013-01-3
[5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]-cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl dihydrogen phosphate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1428929-72-9
di-tert-butyl [5-[[4-[[3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-methylene]cyclohexyl]carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methyl phosphate

: disodium [5-[[4-[[3-[[S-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methylene]cyclohexyl] carbamoyl]pyrrolo[2,3-b]pyridin-1-yl]methylphosphate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2: sodium carbonate / water; acetone / 4 h / 20 °C

With sodium carbonate; trifluoroacetic acid; In dichloromethane; water; acetone;