N-{9-(2-ethoxy-3,4-dioxocyclobut-1-enyl)-11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide

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Chemical Name:N-{9-(2-ethoxy-3,4-dioxocyclobut-1-enyl)-11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide
CAS No.:473912-50-4
Molecular Formula:C₃₂H₄₀F₃N₇O₁₀S
Molecular Weight:771.772
Hs Code.:

Synonyms:N-{9-(2-ethoxy-3,4-dioxocyclobut-1-enyl)-11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide

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Chemical Property of N-{9-(2-ethoxy-3,4-dioxocyclobut-1-enyl)-11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide

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Technology Process of N-{9-(2-ethoxy-3,4-dioxocyclobut-1-enyl)-11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide

There total 5 articles about N-{9-(2-ethoxy-3,4-dioxocyclobut-1-enyl)-11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 5231-87-8
3,4-diethoxy-3-cyclobuten-1,2-dione

: 473912-49-1
N-{11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide

: 473912-50-4
N-{9-(2-ethoxy-3,4-dioxocyclobut-1-enyl)-11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide

Guidance literature:: In ethanol; at 20 ℃; for 19h;
DOI:10.1002/1521-3773(20020703)41:13<2293::AID-ANIE2293>3.0.CO;2-9 DOI:10.1002/hlca.200390346

Reference yield:

: 212207-96-0
2-<5-nitro-3-(3-trifluoromethyl-1,2-diazirin-3-yl)phenoxy>ethanal

: 473912-50-4
N-{9-(2-ethoxy-3,4-dioxocyclobut-1-enyl)-11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / CF₃COOH; sdodium cyanoborohydride / methanol / 30 h / 20 °C

2: 91 percent / ethanol / 19 h / 20 °C

With sodium tetrahydroborate; trifluoroacetic acid; In methanol; ethanol;
DOI:10.1002/hlca.200390346

Reference yield:

: 212208-07-6
3-[3-nitro-5-(prop-2-enyloxy)phenyl]-3-(trifluoromethyl)-3H-diazirine

: 473912-50-4
N-{9-(2-ethoxy-3,4-dioxocyclobut-1-enyl)-11-{3-nitro-5-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy}-3,6-dioxa-9-azaundecyl}biotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: OsO₄; N-methylmorpholine-N-oxide / acetone; H₂O / 3 h / 20 °C

1.2: 74 percent / NaIO₄ on silica gel / 24 h / 20 °C

2.1: 60 percent / TFA; NaBH₃CN / methanol / 32 h / 20 °C / pH 7.0

3.1: 91 percent / ethanol / 19 h / 20 °C

With osmium(VIII) oxide; sodium cyanoborohydride; 4-methylmorpholine N-oxide; trifluoroacetic acid; In methanol; ethanol; water; acetone;
DOI:10.1002/1521-3773(20020703)41:13<2293::AID-ANIE2293>3.0.CO;2-9