methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate

Base Information

Chemical Name:methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate
CAS No.:959991-36-7
Molecular Formula:C₃₀H₂₉Cl₂N₃O₅
Molecular Weight:582.483
Hs Code.:

Synonyms:methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate

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Chemical Property of methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate

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Technology Process of methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate

There total 1 articles about methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 38427-94-0
N-(tert-butoxycarbonyl)-2-aminopyridine

: 959991-36-7
methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate

Guidance literature:: methyl N-(2,6-dichlorobenzoyl)-4-(3-hydroxyprop-1-yn-1-yl)-L-phenylalaninate; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 2h;

N-(tert-butoxycarbonyl)-2-aminopyridine; With sodium hydride; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 3h;

Reference yield: 98.0%

: 959991-36-7
methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate

: 959991-38-9
methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]propyl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate

Guidance literature:: With hydrogen; 10% Pt/activated carbon; In methanol; for 5h; under 1140.08 Torr;

Reference yield: 97.0%

: 959991-36-7
methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate

: methyl N-(2,6-dichlorobenzoyl)-4-[3-(pyridin-2-ylamino)prop-1-yn-1-yl]-L-phenylalaninate

Guidance literature:: methyl 4-{3-[(tert-butoxycarbonyl)(pyridin-2-yl)amino]prop-1-yn-1-yl}-N-(2,6-dichlorobenzoyl)-L-phenylalaninate; With trifluoroacetic acid; In dichloromethane;

With sodium hydrogencarbonate; In water; ethyl acetate; pH=7;