(3R)-3-[(2-chlorobenzoyl)amino]-N-ethyl-N-[1-(7H-purin-6-yl)piperidin-4-yl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

Base Information

Chemical Name:(3R)-3-[(2-chlorobenzoyl)amino]-N-ethyl-N-[1-(7H-purin-6-yl)piperidin-4-yl]-2,3-dihydro-1H-indene-5-carboxylic acid amide
CAS No.:1365139-25-8
Molecular Formula:C₂₉H₃₀ClN₇O₂
Molecular Weight:544.056
Hs Code.:

Synonyms:(3R)-3-[(2-chlorobenzoyl)amino]-N-ethyl-N-[1-(7H-purin-6-yl)piperidin-4-yl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

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Chemical Property of (3R)-3-[(2-chlorobenzoyl)amino]-N-ethyl-N-[1-(7H-purin-6-yl)piperidin-4-yl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

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Technology Process of (3R)-3-[(2-chlorobenzoyl)amino]-N-ethyl-N-[1-(7H-purin-6-yl)piperidin-4-yl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

There total 6 articles about (3R)-3-[(2-chlorobenzoyl)amino]-N-ethyl-N-[1-(7H-purin-6-yl)piperidin-4-yl]-2,3-dihydro-1H-indene-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1246506-61-5
(3R)-3-[(2-chloro-benzoyl)amino]-2,3-dihydro-1H-indene-5-carboxylic acid

: 1178963-75-1
N-ethyl-1-(7H-purin-6-yl)piperidin-4-amine

: 1365139-25-8
(3R)-3-[(2-chlorobenzoyl)amino]-N-ethyl-N-[1-(7H-purin-6-yl)piperidin-4-yl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

Guidance literature:: (3R)-3-[(2-chloro-benzoyl)amino]-2,3-dihydro-1H-indene-5-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; cooling with ice;

N-ethyl-1-(7H-purin-6-yl)piperidin-4-amine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 1246509-78-3
(R)-tert-butyl 6-bromo-2,3-dihydro-1H-inden-1-yl carbamate

: 1365139-25-8
(3R)-3-[(2-chlorobenzoyl)amino]-N-ethyl-N-[1-(7H-purin-6-yl)piperidin-4-yl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / dimethyl sulfoxide / 16 h / 75 °C / 4137.29 Torr / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: water; lithium hydroxide / methanol / 25 °C

4.2: pH 2

5.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / cooling with ice

5.2: 16 h / 20 °C

With water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1055961-36-8,1213110-51-0
(R)-6-bromo-2,3-dihydro-1H-inden-1-amine

: 1365139-25-8
(3R)-3-[(2-chlorobenzoyl)amino]-N-ethyl-N-[1-(7H-purin-6-yl)piperidin-4-yl]-2,3-dihydro-1H-indene-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 16 h / 0 °C

2.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / dimethyl sulfoxide / 16 h / 75 °C / 4137.29 Torr / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5.1: water; lithium hydroxide / methanol / 25 °C

5.2: pH 2

6.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / cooling with ice

6.2: 16 h / 20 °C

With water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;