(S)-4-(4-(4-fluorophenyl)-5,5-dimethyl-2-oxooxazolidin-3-yl)-N-(quinolin-8-yl)benzamide

Base Information

Chemical Name:(S)-4-(4-(4-fluorophenyl)-5,5-dimethyl-2-oxooxazolidin-3-yl)-N-(quinolin-8-yl)benzamide
CAS No.:1456504-76-9
Molecular Formula:C₂₇H₂₂FN₃O₃
Molecular Weight:455.488
Hs Code.:

Synonyms:(S)-4-(4-(4-fluorophenyl)-5,5-dimethyl-2-oxooxazolidin-3-yl)-N-(quinolin-8-yl)benzamide

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Chemical Property of (S)-4-(4-(4-fluorophenyl)-5,5-dimethyl-2-oxooxazolidin-3-yl)-N-(quinolin-8-yl)benzamide

Chemical Property:

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Technology Process of (S)-4-(4-(4-fluorophenyl)-5,5-dimethyl-2-oxooxazolidin-3-yl)-N-(quinolin-8-yl)benzamide

There total 6 articles about (S)-4-(4-(4-fluorophenyl)-5,5-dimethyl-2-oxooxazolidin-3-yl)-N-(quinolin-8-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1203050-38-7
4-iodo-N-(quinolin-8-yl)benzamide

: 1456506-82-3
(S)-4-(4-fluorophenyl)-5,5-dimethyloxazolidin-2-one

: 1456504-76-9
(S)-4-(4-(4-fluorophenyl)-5,5-dimethyl-2-oxooxazolidin-3-yl)-N-(quinolin-8-yl)benzamide

Guidance literature:: With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 140 ℃; for 2h; Inert atmosphere; Sealed tube; Microwave irradiation;

Reference yield:

: 19883-57-9
(S)-2-amino-2-(4-fluorophenyl)acetic acid

: 1456504-76-9
(S)-4-(4-(4-fluorophenyl)-5,5-dimethyl-2-oxooxazolidin-3-yl)-N-(quinolin-8-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2 h / Reflux

2: diethyl ether / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / 0 °C

4: potassium phosphate; N,N`-dimethylethylenediamine; copper(l) iodide / 1,4-dioxane / 2 h / 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With potassium phosphate; copper(l) iodide; thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether;

Reference yield:

: 170902-74-6,170902-76-8
(S)-methyl 2-amino-2-(4-fluorophenyl)acetate

: 1456504-76-9
(S)-4-(4-(4-fluorophenyl)-5,5-dimethyl-2-oxooxazolidin-3-yl)-N-(quinolin-8-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / 0 °C

3: potassium phosphate; N,N`-dimethylethylenediamine; copper(l) iodide / 1,4-dioxane / 2 h / 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With potassium phosphate; copper(l) iodide; N-ethyl-N,N-diisopropylamine; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether;