2,4-dichloro-N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide

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Chemical Name:2,4-dichloro-N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide
CAS No.:1208130-70-4
Molecular Formula:C₂₂H₂₅Cl₂N₇O₆
Molecular Weight:554.39
Hs Code.:

Synonyms:2,4-dichloro-N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide

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Chemical Property of 2,4-dichloro-N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide

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Technology Process of 2,4-dichloro-N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide

There total 5 articles about 2,4-dichloro-N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.4%

: C₂₃H₂₆Cl₂N₆O₆

: 1208130-70-4
2,4-dichloro-N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide

Guidance literature:: With hydroxylamine potassium salt; In methanol;
DOI:10.1007/s00044-017-1999-2

Reference yield:

: 74-79-3,25212-18-4
L-arginine

: 1208130-70-4
2,4-dichloro-N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: nitric acid; sulfuric acid

2: acetyl chloride

3: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / -5 °C

4: hydroxylamine potassium salt / methanol

With hydroxylamine potassium salt; sulfuric acid; nitric acid; benzotriazol-1-ol; acetyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1007/s00044-017-1999-2

Reference yield:

: 50-84-0
2,4 dichlorobenzoic acid

: 1208130-70-4
2,4-dichloro-N-((S)-1-((S)-1-(hydroxyamino)-5-(3-nitroguanidino)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl) benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / tetrahydrofuran / -15 °C

2: sodium hydroxide; water / methanol

3: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / -5 °C

4: hydroxylamine potassium salt / methanol

With 4-methyl-morpholine; hydroxylamine potassium salt; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1007/s00044-017-1999-2