tert-butyl (Z)-3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enyl carbonate

Base Information

Chemical Name:tert-butyl (Z)-3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enyl carbonate
CAS No.:950676-33-2
Molecular Formula:C₂₅H₃₃NO₇S
Molecular Weight:491.606
Hs Code.:

Synonyms:tert-butyl (Z)-3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enyl carbonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (Z)-3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enyl carbonate

Chemical Property:

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Technology Process of tert-butyl (Z)-3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enyl carbonate

There total 6 articles about tert-butyl (Z)-3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 950676-27-4
3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enol

: 24424-99-5
di-tert-butyl dicarbonate

: 950676-33-2
tert-butyl (Z)-3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enyl carbonate

Guidance literature:: With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In dichloromethane;
DOI:10.1016/j.tet.2007.04.097

Reference yield:

: 950676-26-3
3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-ynol

: 950676-33-2
tert-butyl (Z)-3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaBH₄; H₂; ethylenediamine / Ni(OAc)2 / ethanol / 20 °C

2: 92 percent / Bu₄NI; aq. NaOH / CH₂Cl₂

With sodium hydroxide; sodium tetrahydroborate; hydrogen; tetra-(n-butyl)ammonium iodide; ethylenediamine; nickel diacetate; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2007.04.097

Reference yield:

: 950676-25-2
1-iodo-4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]benzene

: 950676-33-2
tert-butyl (Z)-3-{4,5-dimethoxy-2-[2-(4-methylbenzenesulfonylamino)ethyl]phenyl}prop-2-enyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / CuI; Et₂NH / Pd(PPh₃)2Cl₂ / 20 °C

2: 95 percent / NaBH₄; H₂; ethylenediamine / Ni(OAc)2 / ethanol / 20 °C

3: 92 percent / Bu₄NI; aq. NaOH / CH₂Cl₂

With sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; hydrogen; tetra-(n-butyl)ammonium iodide; ethylenediamine; diethylamine; bis-triphenylphosphine-palladium(II) chloride; nickel diacetate; In ethanol; dichloromethane; 1: Sonogashira coupling;
DOI:10.1016/j.tet.2007.04.097