ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(2-nitrophenyl)cyclohexanecarboxylate

Base Information

• Chemical Name: ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(2-nitrophenyl)cyclohexanecarboxylate
• CAS No.: 1033363-12-0
• Molecular Formula: C₁₈H₂₂N₂O₈
• Molecular Weight: 394.381
• Mol file: 1033363-12-0.mol

Synonyms:ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(2-nitrophenyl)cyclohexanecarboxylate

Chemical Property of ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(2-nitrophenyl)cyclohexanecarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(2-nitrophenyl)cyclohexanecarboxylate

There total 2 articles about ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(2-nitrophenyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-acetyl-5-oxohexanoic acid ethyl ester (35490-05-2) + 1-nitro-2-(2-nitrovinyl)benzene (5670-66-6,5670-67-7,3156-39-6) → ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(2-nitrophenyl)cyclohexanecarboxylate (1033363-12-0)

Guidance literature:

With (R)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine; In diethyl ether; at 23 ℃; for 24h; optical yield given as %ee; stereoselective reaction;

DOI:10.1021/ol8007183

Reference yield: 94.0%

→ ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(2-nitrophenyl)cyclohexanecarboxylate (1033363-12-0)

Guidance literature:

upstream raw materials:

2-acetyl-5-oxohexanoic acid ethyl ester

1-nitro-2-(2-nitrovinyl)benzene