5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazol-2-amine

Base Information

• Chemical Name: 5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazol-2-amine
• CAS No.: 1231978-09-8
• Molecular Formula: C₂₂H₂₅N₇O₈S
• Molecular Weight: 547.549
• Mol file: 1231978-09-8.mol

Synonyms:5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazol-2-amine

Chemical Property of 5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazol-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazol-2-amine

There total 4 articles about 5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N'-[N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)thiocarbamoyl]-2-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanyl)acetohydrazide (1231978-45-2) → 5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazol-2-amine (1231978-09-8)

Guidance literature:

With mercury(II) diacetate; In ethanol; Reflux;

DOI:10.1016/j.carres.2011.01.010

Reference yield:

<<1-(4-methylphenyl)-1H-tetrazol-5-yl>thio>-acetic acid hydrazide (13980-82-0) → 5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazol-2-amine (1231978-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 4 h / Reflux

2: mercury(II) diacetate / ethanol / Reflux

With mercury(II) diacetate; In ethanol; benzene;

DOI:10.1016/j.carres.2011.01.010

Reference yield:

<<1-(4-methylphenyl)-1H-tetrazol-5-yl>thio>-ethyl acetate (14094-61-2) → 5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-1,3,4-oxadiazol-2-amine (1231978-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 4 h / Reflux

2: benzene / 4 h / Reflux

3: mercury(II) diacetate / ethanol / Reflux

With mercury(II) diacetate; hydrazine hydrate; In ethanol; benzene;

DOI:10.1016/j.carres.2011.01.010

upstream raw materials:

N'-[N-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)thiocarbamoyl]-2-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanyl)acetohydrazide

<<1-(4-methylphenyl)-1H-tetrazol-5-yl>thio>-ethyl acetate

<<1-(4-methylphenyl)-1H-tetrazol-5-yl>thio>-acetic acid hydrazide

1-(4-methylphenyl)tetrazole-5-thiol

Downstream raw materials:

5-(1-(4-methylphenyl)-1H-tetrazol-5-ylsulfanylmethyl)-N-β-D-xylopyranosyl-1,3,4-oxadiazol-2-amine