(4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one

Base Information

Chemical Name:(4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one
CAS No.:82507-49-1
Molecular Formula:C₂₀H₂₇NO₄
Molecular Weight:345.439
Hs Code.:

Synonyms:(4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one

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Chemical Property of (4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one

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Technology Process of (4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one

There total 4 articles about (4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 82507-48-0
(S)-(+)-2,4-dimethylpent-4-enal

: 158930-33-7
(4R,5S)-(CHCH₃CHPhOCONCOB(n-Bu)2CHCH₃)

: 82507-49-1
(4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: at -78 ℃;
DOI:10.1016/S0040-4039(00)86954-3

Reference yield:

: 80719-70-6
(4R,5S)-3-<(2S)-1-oxo-2,4-dimethylpent-4-enyl>-4-methyl-5-phenyloxazolidin-2-one

: 82507-49-1
(4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / LiAlH₄ / diethyl ether / 3.5 h / 0 - 25 °C

2: 87 percent / triethylamine, dimethyl sulfoxide, pyridine sulfur trioxide complex / 0.25 h / 25 °C

3: 1.) di-n-butylboryl triflate, triethylamine / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) CH₂Cl₂, a) -78 deg C, 30 min, b) 0 deg C, 1 h

With lithium aluminium tetrahydride; di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In diethyl ether;
DOI:10.1021/ja00020a025

Reference yield:

: 82507-47-9
(S)-(-)-2,4-dimethylpent-4-en-1-ol

: 82507-49-1
(4S,5S)-3-<(2R,3S,4S)-1-oxo-2,4,6-trimethyl-3-hydroxyhept-6-enyl>-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / triethylamine, dimethyl sulfoxide, pyridine sulfur trioxide complex / 0.25 h / 25 °C

2: 1.) di-n-butylboryl triflate, triethylamine / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) CH₂Cl₂, a) -78 deg C, 30 min, b) 0 deg C, 1 h

With di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine;
DOI:10.1021/ja00020a025