Technology Process of 4-Benzyloxy-benzoic acid (2aR,3R,4R,4aS,6S,7aR,7bR)-6-ethoxy-2a,3-dihydroxy-octahydro-1,7-dioxa-cyclopenta[cd]inden-4-yl ester
There total 9 articles about 4-Benzyloxy-benzoic acid (2aR,3R,4R,4aS,6S,7aR,7bR)-6-ethoxy-2a,3-dihydroxy-octahydro-1,7-dioxa-cyclopenta[cd]inden-4-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 72 percent / LiAlH4 / tetrahydrofuran / 16 h / Ambient temperature
2: 81 percent / PTSA, CuSO4 anh., / CH2Cl2 / 16 h / Ambient temperature
3: 85 percent / mCPBA / CH2Cl2 / 16 h / Ambient temperature
4: 71 percent / (COCl)2, Et3N / CH2Cl2; dimethylsulfoxide / 1.5 h / -60 - 25 °C
5: 87 percent / Al-Hg / ethanol; tetrahydrofuran / 4 h / Ambient temperature
6: 67 percent / (COCl)2, Et3N / CH2Cl2; dimethylsulfoxide / 2.5 h / -60 °C
8: 78 percent / OsO4, NMMO, H2O / acetone / 16 h / Ambient temperature
9: 82 percent / Et3N / CH2Cl2 / 216 h / Ambient temperature
With
osmium(VIII) oxide; lithium aluminium tetrahydride; oxalyl dichloride; aluminium amalgam; water; toluene-4-sulfonic acid; copper(II) sulfate; 4-methylmorpholine N-oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1016/S0040-4039(01)80819-4
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 81 percent / PTSA, CuSO4 anh., / CH2Cl2 / 16 h / Ambient temperature
2: 85 percent / mCPBA / CH2Cl2 / 16 h / Ambient temperature
3: 71 percent / (COCl)2, Et3N / CH2Cl2; dimethylsulfoxide / 1.5 h / -60 - 25 °C
4: 87 percent / Al-Hg / ethanol; tetrahydrofuran / 4 h / Ambient temperature
5: 67 percent / (COCl)2, Et3N / CH2Cl2; dimethylsulfoxide / 2.5 h / -60 °C
7: 78 percent / OsO4, NMMO, H2O / acetone / 16 h / Ambient temperature
8: 82 percent / Et3N / CH2Cl2 / 216 h / Ambient temperature
With
osmium(VIII) oxide; oxalyl dichloride; aluminium amalgam; water; toluene-4-sulfonic acid; copper(II) sulfate; 4-methylmorpholine N-oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1016/S0040-4039(01)80819-4
