(2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol

Base Information

• Chemical Name: (2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol
• CAS No.: 1163305-45-0
• Molecular Formula: C₁₇H₁₇IO₂S
• Molecular Weight: 412.291
• Mol file: 1163305-45-0.mol

Synonyms:(2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol

Chemical Property of (2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol

There total 1 articles about (2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(SS)-(2-(buta-2,3-dienyl)phenyl)-p-tolylsulfoxide (1072809-18-7) → (2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol (1163305-45-0)

Guidance literature:

With lithium acetate; water; iodine; In acetonitrile; at 0 ℃; for 2h; regioselective reaction;

DOI:10.1002/anie.200900448

Reference yield: 99.0%

(2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol (1163305-45-0) → (2R)-1-phenylbut-3-en-2-ol (151636-81-6)

Guidance literature:

(2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With water; ammonium chloride;

DOI:10.1002/anie.200900448

Reference yield: 95.0%

(2R,S(R))-3-iodo-1-[2-(p-tolylsulfinyl)phenyl]but-3-en-2-ol (1163305-45-0) → (2R,S(R))-1-[2-(p-tolylsulfinyl)phenyl]but-3-yn-2-ol (1163305-59-6)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.200900448

upstream raw materials:

(S_S)-(2-(buta-2,3-dienyl)phenyl)-p-tolylsulfoxide

Downstream raw materials:

(2R,S(R))-1-[2-(p-tolylsulfinyl)phenyl]but-3-yn-2-ol

(S)-1-phenylbutan-2-ol

(2R)-1-phenylbutan-2-ol

(2R)-1-phenylbut-3-en-2-ol