1-<<5-(R)-<(tert-butyloxy)carbonyl>amino>-6-hydroxyhexyl>-3-o-tolylurea

Base Information

Chemical Name:1-<<5-(R)-<(tert-butyloxy)carbonyl>amino>-6-hydroxyhexyl>-3-o-tolylurea
CAS No.:166446-73-7
Molecular Formula:C₁₉H₃₁N₃O₄
Molecular Weight:365.473
Hs Code.:

Synonyms:1-<<5-(R)-<(tert-butyloxy)carbonyl>amino>-6-hydroxyhexyl>-3-o-tolylurea

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Chemical Property of 1-<<5-(R)-<(tert-butyloxy)carbonyl>amino>-6-hydroxyhexyl>-3-o-tolylurea

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Technology Process of 1-<<5-(R)-<(tert-butyloxy)carbonyl>amino>-6-hydroxyhexyl>-3-o-tolylurea

There total 1 articles about 1-<<5-(R)-<(tert-butyloxy)carbonyl>amino>-6-hydroxyhexyl>-3-o-tolylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 614-68-6
2-tolyl isocyanate

: 166446-73-7
1-<<5-(R)-<(tert-butyloxy)carbonyl>amino>-6-hydroxyhexyl>-3-o-tolylurea

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1 N aq. NaOH / 15 h

2: 1.) isobutyl chloroformate, diisopropylethylamine, 2.) lithium aluminum hydride / 1.) THF, 0 deg C, 1 h, 2.) THF, Et₂O, RT, 24 h

With sodium hydroxide; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate;
DOI:10.1021/jm00017a022

Reference yield:

: 166446-73-7
1-<<5-(R)-<(tert-butyloxy)carbonyl>amino>-6-hydroxyhexyl>-3-o-tolylurea

: 167980-81-6
2-<<(adamantan-2-yloxy)carbonyl>amino>-N-<2-(R)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexyl>-3-(1H-indol-3-yl)-2-(S)-methylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP, triethylamine / CH₂Cl₂ / 2.25 h / Ambient temperature

2: sodium azide / dimethylformamide / 1.5 h / 80 °C

3: 95 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 760 Torr

4: 75 percent / 1-hydroxybenzotriazole, EDC / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00017a022

Reference yield:

: 166446-73-7
1-<<5-(R)-<(tert-butyloxy)carbonyl>amino>-6-hydroxyhexyl>-3-o-tolylurea

: N-<1-<<<2-(R)-<<(adamantan-2-yloxy)carbonyl>amino>-3-(1H-indol-3-yl)-2-(R)-methylpropionyl>amino>methyl>5-(3-o-tolylureido)pentyl>succinamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: DMAP, triethylamine / CH₂Cl₂ / 2.25 h / Ambient temperature

2: sodium azide / dimethylformamide / 1.5 h / 80 °C

3: 95 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 760 Torr

4: 1-hydroxybenzotriazole, EDC / CH₂Cl₂ / 24 h / Ambient temperature

5: 4 N HCl / dioxane / 1 h / Ambient temperature

6: triethylamine / CH₂Cl₂ / 0.5 h / Irradiation

With hydrogenchloride; dmap; sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00017a022