(3S)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

Base Information

Chemical Name:(3S)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile
CAS No.:1572927-98-0
Molecular Formula:C₂₂H₂₂F₃N₅O₃S
Molecular Weight:493.51
Hs Code.:

Synonyms:(3S)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

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Chemical Property of (3S)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

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Technology Process of (3S)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

There total 18 articles about (3S)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1589535-20-5
C₂₇H₃₀F₃N₅O₅S

: 1572927-97-9
(3R)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

: 1572927-98-0
(3S)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 1572927-97-9
(3R)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

: 1572927-98-0
(3S)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.67 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: water / 1,4-dioxane / 24 h / 85 °C

3.1: toluene-4-sulfonic acid / acetone / 40 h / 20 °C

4.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

5.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 1.5 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 20 °C

7.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

8.1: water; N,N-dimethyl-formamide / 0.33 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h

With trifluorormethanesulfonic acid; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium tert-butylate; water; toluene-4-sulfonic acid; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; sodium t-butanolate; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1450620-16-2
tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate

: 1572927-97-9
(3R)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

: 1572927-98-0
(3S)-3-(4-((2S)-4-((6-amino-3-pyridinyl)sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)phenyl)-4,4,4-trifluoro-3-hydroxybutanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

3: water; N,N-dimethyl-formamide / 0.33 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h

With triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;