(1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanecarbonyl Chloride

Base Information

• Chemical Name: (1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanecarbonyl Chloride
• CAS No.: 1207722-22-2
• Molecular Formula: C₁₁H₁₉ClO
• Molecular Weight: 202.724
• Mol file: 1207722-22-2.mol

Synonyms:(1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanecarbonyl Chloride

Chemical Property of (1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanecarbonyl Chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanecarbonyl Chloride

There total 6 articles about (1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanecarbonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1S,2S,5R)-2-isopropyl-5-methylcyclohexane-1-carboxylic acid (70985-58-9) → (1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanecarbonyl Chloride (1207722-22-2)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.3390/molecules26040906

Reference yield:

menthylformic acid (663218-94-8) → (1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanecarbonyl Chloride (1207722-22-2) + (1R,2S,5R)-2-isopropyl-5-methylcyclohexane-1-carbonyl chloride (108235-80-9)

Guidance literature:

With phosphorus trichloride; In n-heptane; at 75 - 80 ℃; for 4.51667h;

Reference yield:

(1S,2S,5R)-1-cyano-2-isopropyl-5-methylcyclohexane (180978-26-1,1217664-77-1,439924-29-5) → (1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexanecarbonyl Chloride (1207722-22-2)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran

2: Jones reagent / diethyl ether

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Inert atmosphere

With Jones reagent; oxalyl dichloride; diisobutylaluminium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.3390/molecules26040906

upstream raw materials:

menthylformic acid

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl methanesulfonate

(1S,2S,5R)-1-cyano-2-isopropyl-5-methylcyclohexane

(1S,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde