N-benzyloxycarbonyl aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine methyl ester

Base Information

• Chemical Name: N-benzyloxycarbonyl aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine methyl ester
• CAS No.: 1582265-91-5
• Molecular Formula: C₂₆H₃₁N₃O₇
• Molecular Weight: 497.548
• Mol file: 1582265-91-5.mol

Synonyms:N-benzyloxycarbonyl aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine methyl ester

Chemical Property of N-benzyloxycarbonyl aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine methyl ester

There total 2 articles about N-benzyloxycarbonyl aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

C18H25N3O5 + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine methyl ester (1582265-91-5)

Guidance literature:

With triethylamine; In dichloromethane; toluene; at 20 ℃;

DOI:10.1071/CH13464

Reference yield:

C37H39N3O5 (1582265-90-4) → N-benzyloxycarbonyl aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine methyl ester (1582265-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / methanol; dichloromethane / 0.67 h / 0 °C

2: triethylamine / dichloromethane; toluene / 20 °C

With triethylamine; trifluoroacetic acid; In methanol; dichloromethane; toluene;

DOI:10.1071/CH13464

Reference yield: 17.0%

N-benzyloxycarbonyl aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine methyl ester (1582265-91-5) + benzyl alcohol (100-51-6,185532-71-2) → aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine benzyl ester (1582265-92-6) + C32H35N3O7 (1582265-99-3)

Guidance literature:

With Otera’s catalyst; In toluene; at 100 ℃; for 28h; chemoselective reaction;

DOI:10.1071/CH13464

upstream raw materials:

benzyl chloroformate

C₃₇H₃₉N₃O₅

Downstream raw materials:

aziridine-2-carboxyl-(Nε-benzyloxycarbonyl)lysine benzyl ester

C₃₂H₃₅N₃O₇