tert-butyl (E)-3-(3-methoxyphenyl)propenoate

Base Information

• Chemical Name: tert-butyl (E)-3-(3-methoxyphenyl)propenoate
• CAS No.: 181517-73-7
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 181517-73-7.mol

Synonyms:tert-butyl (E)-3-(3-methoxyphenyl)propenoate

Chemical Property of tert-butyl (E)-3-(3-methoxyphenyl)propenoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tert-butyl (E)-3-(3-methoxyphenyl)propenoate

There total 12 articles about tert-butyl (E)-3-(3-methoxyphenyl)propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methoxyphenyl bromide (2398-37-0) + tert-Butyl acrylate (1663-39-4,25232-27-3) → tert-butyl (E)-3-(3-methoxyphenyl)propenoate (181517-73-7)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; toluene-4-sulfonic acid; triethylamine; sodium chloride; In water; at 22 ℃; for 14h; Inert atmosphere;

DOI:10.1021/jo200746y

Reference yield: 93.0%

tert-butyl diethylphosphonoacetate (27784-76-5) + 3-methoxy-benzaldehyde (591-31-1) → tert-butyl (E)-3-(3-methoxyphenyl)propenoate (181517-73-7)

Guidance literature:

tert-butyl diethylphosphonoacetate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

3-methoxy-benzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1016/j.tetasy.2007.06.008

Reference yield: 62.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 3-methoxy-1-iodobenzene (766-85-8) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → (E)-3-(3'-methoxybiphenyl-2-yl)acrylic acid tert-butyl ester (957472-47-8) + tert-butyl (E)-3-(3-methoxyphenyl)propenoate (181517-73-7)

Guidance literature:

With cesium fluoride; tris-(o-tolyl)phosphine; palladium diacetate; In acetonitrile; at 45 ℃; for 4h; Further Variations:; Temperatures; Reagents; Catalysts; Solvents; time; Product distribution;

DOI:10.1021/ol702584t

upstream raw materials:

3-methoxyphenyl bromide

acrylic acid n-butyl ester

tert-Butyl acrylate

tert-butyl diethylphosphonoacetate

Downstream raw materials:

tert-butyl (3R,αS)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3-methoxyphenyl)propanoate

tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-3-(3-methoxyphenyl)propanoate

trans-3-methoxycinnamic acid