2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE

Base Information

• Chemical Name: 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE
• CAS No.: 65224-66-0
• Molecular Formula: C5H4 Cl N3 O3
• Molecular Weight: 189.56
• Hs Code.: 2933599090
• Mol file: 65224-66-0.mol

Synonyms:4(1H)-Pyrimidinone,2-chloro-6-methyl-5-nitro- (9CI); 2-Chloro-4-hydroxy-6-methyl-5-nitropyrimidine

Chemical Property of 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• Boiling Point: 276℃
• Flash Point: 121℃
• PSA: 91.83000
• Density: 1.80
• LogP: 1.57540

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-6-methyl-5-nitro-4(1h)-pyrimidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE

There total 3 articles about 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,4-dichloro-6-methyl-5-nitropyrimidine (13162-26-0) → 2-chloro-6-methyl-5-nitro-3H-pyrimidin-4-one (65224-66-0)

Guidance literature:

With sodium acetate; acetic acid; In ethanol;

DOI:10.1016/j.bmcl.2006.06.066

Reference yield:

6-methyl-5-nitropyrimidine-2,4-diol (16632-21-6) → 2-chloro-6-methyl-5-nitro-3H-pyrimidin-4-one (65224-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / Et₄NCl; N,N-dimethylaniline; POCl₃ / acetonitrile / Heating

2: 79 percent / NaOAc; AcOH / ethanol; H₂O

With tetraethylammonium chloride; sodium acetate; acetic acid; N,N-dimethyl-aniline; trichlorophosphate; In ethanol; water; acetonitrile;

DOI:10.1016/j.bmcl.2007.01.109

Reference yield:

→ 2-chloro-6-methyl-5-nitro-3H-pyrimidin-4-one (65224-66-0)

Guidance literature:

2,4-Dichlor-6-methyl-5-nitropyrimidin, H2O;

DOI:10.1039/j39710000679

upstream raw materials:

2,4-dichloro-6-methyl-5-nitropyrimidine

6-methyl-5-nitropyrimidine-2,4-diol

Downstream raw materials:

2-ethoxy-6-methyl-5-nitro-pyrimidin-4-ol

C₁₅H₁₈N₄O₃

C₁₃H₁₄N₄O₃

C₁₁H₁₆N₄O₃