1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-fluorophenyl)-2(1H,3H)-imidazolone

Base Information

Chemical Name:1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-fluorophenyl)-2(1H,3H)-imidazolone
CAS No.:155432-40-9
Molecular Formula:C₂₁H₁₈F₃N₅O₂
Molecular Weight:429.401
Hs Code.:

Synonyms:1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-fluorophenyl)-2(1H,3H)-imidazolone

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Chemical Property of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-fluorophenyl)-2(1H,3H)-imidazolone

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Technology Process of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-fluorophenyl)-2(1H,3H)-imidazolone

There total 8 articles about 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-fluorophenyl)-2(1H,3H)-imidazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 288-88-0
1,2,4-Triazole

: 1-{(R)-1-[(R)-2-(2,4-Difluoro-phenyl)-oxiranyl]-ethyl}-3-(4-fluoro-phenyl)-1,3-dihydro-imidazol-2-one

: 155432-40-9
1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-fluorophenyl)-2(1H,3H)-imidazolone

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 5h;
DOI:10.1248/cpb.47.351

Reference yield:

: 1195-45-5
para-fluorophenyl isocyanate

: 155432-40-9
1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-fluorophenyl)-2(1H,3H)-imidazolone

Guidance literature:: Multi-step reaction with 4 steps

1: 1 h / Ambient temperature

2: 0.48N HCl / ethanol; H₂O / 48 h / Ambient temperature

3: 1.) NaH / 1.) DMF, -10 deg C, 2.) DMF, a) -10 deg C, 10 min, b) 0 deg C, 20 min

4: 74 percent / NaH / dimethylformamide / 5 h / 50 °C

With hydrogenchloride; sodium hydride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.351

Reference yield:

: 138373-69-0
(1S)-1-<(2S)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol

: 155432-40-9
1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-fluorophenyl)-2(1H,3H)-imidazolone

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylethylamine / CH₂Cl₂ / 0.67 h / -78 - -20 °C

2: 1.) NaH / 1.) DMF, -10 deg C, 2.) DMF, a) -10 deg C, 10 min, b) 0 deg C, 20 min

3: 74 percent / NaH / dimethylformamide / 5 h / 50 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.351