(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl (R)-α-Methoxy-α-(trifluoromethyl)phenylacetate

Base Information

Chemical Name:(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl (R)-α-Methoxy-α-(trifluoromethyl)phenylacetate
CAS No.:124483-23-4
Molecular Formula:C₂₉H₃₀F₃NO₅
Molecular Weight:529.556
Hs Code.:

Synonyms:(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl (R)-α-Methoxy-α-(trifluoromethyl)phenylacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl (R)-α-Methoxy-α-(trifluoromethyl)phenylacetate

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Technology Process of (2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl (R)-α-Methoxy-α-(trifluoromethyl)phenylacetate

There total 9 articles about (2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl (R)-α-Methoxy-α-(trifluoromethyl)phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 124483-25-6
(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)propyl alcohol

: 124483-23-4
(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl (R)-α-Methoxy-α-(trifluoromethyl)phenylacetate

Guidance literature:: With dmap; triethylamine; In chloroform; 1.)0 deg C, 2 h, 2.)25 deg C;
DOI:10.1021/jo00292a052

Reference yield:

: 103632-75-3
2-(1-Naphthylmethylidene)succinic anhydride

: 124483-23-4
(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl (R)-α-Methoxy-α-(trifluoromethyl)phenylacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / ethyl acetate

2: 97.5 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

3: 28 percent / 1,3-dicyclohexylcarbodiimide / (N,N-dimethylamino)pyridine / CHCl₃ / 1.)0 deg C, 2 h, 2.)25 deg C,

4: 78 percent / NaOH

5: triethylamine / tetrahydrofuran / 1 h / 0 °C

6: NaBH₄ / tetrahydrofuran; H₂O / 1.)0 deg C, 1 h, 2.)25 deg C, 15 min.

7: 93 percent / triethylamine, (N,N-dimethylamino)pyridine / CHCl₃ / 1.)0 deg C, 2 h, 2.)25 deg C

With dmap; sodium hydroxide; sodium tetrahydroborate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; dmap; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water; ethyl acetate;
DOI:10.1021/jo00292a052

Reference yield:

: 106868-59-1
3-(Morpholinocarbonyl)-2-(1-naphthylmethylidene)propionic acid

: 124483-23-4
(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl (R)-α-Methoxy-α-(trifluoromethyl)phenylacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 97.5 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

2: 28 percent / 1,3-dicyclohexylcarbodiimide / (N,N-dimethylamino)pyridine / CHCl₃ / 1.)0 deg C, 2 h, 2.)25 deg C,

3: 78 percent / NaOH

4: triethylamine / tetrahydrofuran / 1 h / 0 °C

5: NaBH₄ / tetrahydrofuran; H₂O / 1.)0 deg C, 1 h, 2.)25 deg C, 15 min.

6: 93 percent / triethylamine, (N,N-dimethylamino)pyridine / CHCl₃ / 1.)0 deg C, 2 h, 2.)25 deg C

With dmap; sodium hydroxide; sodium tetrahydroborate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; dmap; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water;
DOI:10.1021/jo00292a052