N-[1-[2-cyano-2-[1,3-dihydro-1-(phenylmethyl)-2H-imidazol-2-ylidene]acetyl]cyclohexyl]-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-[1-[2-cyano-2-[1,3-dihydro-1-(phenylmethyl)-2H-imidazol-2-ylidene]acetyl]cyclohexyl]-2,2,2-trifluoroacetamide
• CAS No.: 1373877-37-2
• Molecular Formula: C₂₁H₂₁F₃N₄O₂
• Molecular Weight: 418.419

Synonyms:N-[1-[2-cyano-2-[1,3-dihydro-1-(phenylmethyl)-2H-imidazol-2-ylidene]acetyl]cyclohexyl]-2,2,2-trifluoroacetamide

Chemical Property of N-[1-[2-cyano-2-[1,3-dihydro-1-(phenylmethyl)-2H-imidazol-2-ylidene]acetyl]cyclohexyl]-2,2,2-trifluoroacetamide

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Technology Process of N-[1-[2-cyano-2-[1,3-dihydro-1-(phenylmethyl)-2H-imidazol-2-ylidene]acetyl]cyclohexyl]-2,2,2-trifluoroacetamide

There total 2 articles about N-[1-[2-cyano-2-[1,3-dihydro-1-(phenylmethyl)-2H-imidazol-2-ylidene]acetyl]cyclohexyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-1H-imidazol-2ylacetonitrile (21125-22-4) + C9H11ClF3NO2 → N-[1-[2-cyano-2-[1,3-dihydro-1-(phenylmethyl)-2H-imidazol-2-ylidene]acetyl]cyclohexyl]-2,2,2-trifluoroacetamide (1373877-37-2)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 40 ℃;

DOI:10.1007/s00706-012-0727-3

Reference yield:

1-(trifluoroacetylamino)cyclohexanecarboxylic acid → N-[1-[2-cyano-2-[1,3-dihydro-1-(phenylmethyl)-2H-imidazol-2-ylidene]acetyl]cyclohexyl]-2,2,2-trifluoroacetamide (1373877-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 20 °C

2: pyridine / N,N-dimethyl-formamide / 40 °C

With pyridine; thionyl chloride; In N,N-dimethyl-formamide;

DOI:10.1007/s00706-012-0727-3

Reference yield: 77.0%

N-[1-[2-cyano-2-[1,3-dihydro-1-(phenylmethyl)-2H-imidazol-2-ylidene]acetyl]cyclohexyl]-2,2,2-trifluoroacetamide (1373877-37-2) → 2-amino-3-[1-(phenylmethyl)-1H-imidazol-2-yl]-1-azaspiro[4.5]dec-2-en-4-one (1373877-60-1)

Guidance literature:

With sodium hydroxide; In propan-1-ol; for 3h; Reflux;

DOI:10.1007/s00706-012-0727-3

upstream raw materials:

1-benzyl-1H-imidazol-2ylacetonitrile

Downstream raw materials:

2-amino-3-[1-(phenylmethyl)-1H-imidazol-2-yl]-1-azaspiro[4.5]dec-2-en-4-one

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