N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1H-benzimidazol-1-yl]propyl]-9H-fluorene-9-carboxamide

Base Information

Chemical Name:N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1H-benzimidazol-1-yl]propyl]-9H-fluorene-9-carboxamide
CAS No.:194214-90-9
Molecular Formula:C₄₀H₃₀F₆N₄O₂
Molecular Weight:712.694
Hs Code.:

Synonyms:N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1H-benzimidazol-1-yl]propyl]-9H-fluorene-9-carboxamide

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Chemical Property of N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1H-benzimidazol-1-yl]propyl]-9H-fluorene-9-carboxamide

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Technology Process of N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1H-benzimidazol-1-yl]propyl]-9H-fluorene-9-carboxamide

There total 10 articles about N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1H-benzimidazol-1-yl]propyl]-9H-fluorene-9-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1989-33-9
9H-fluorene-9-carboxylic acid

: 194214-90-9
N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1H-benzimidazol-1-yl]propyl]-9H-fluorene-9-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran / 1 h / 0 °C

1.2: tetrahydrofuran / 30.5 h / 0 - 20 °C

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 1.67 h / 0 - 20 °C

3.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4.1: K₂CO₃ / dimethylformamide / 86 h / 20 °C

5.1: H₂ / 10percent Pd/C / ethanol / 14 h

6.1: Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

With n-butyllithium; oxalyl dichloride; hydrogen; potassium carbonate; triethylamine; N,N-dimethyl-formamide; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000494a

Reference yield:

: 10597-52-1
4-nitro-benzimidazole

: 194214-90-9
N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1H-benzimidazol-1-yl]propyl]-9H-fluorene-9-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 86 h / 20 °C

2: H₂ / 10percent Pd/C / ethanol / 14 h

3: Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

With hydrogen; potassium carbonate; triethylamine; 10percent Pd/C; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000494a

Reference yield:

: 1026583-51-6
9-(3-bromo-propyl)-9H-fluorene-9-carbonyl chloride

: 194214-90-9
N-(2,2,2-Trifluoroethyl)-9-[3-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1H-benzimidazol-1-yl]propyl]-9H-fluorene-9-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: K₂CO₃ / dimethylformamide / 86 h / 20 °C

3: H₂ / 10percent Pd/C / ethanol / 14 h

4: Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

With hydrogen; potassium carbonate; triethylamine; 10percent Pd/C; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000494a