1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate

Base Information

• Chemical Name: 1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate
• CAS No.: 1313236-80-4
• Molecular Formula: C₂HF₃O₂*C₂₅H₂₉N₃O₃S
• Molecular Weight: 565.614
• Mol file: 1313236-80-4.mol

Synonyms:1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate

Chemical Property of 1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate

There total 9 articles about 1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl 2-oxo-1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecane-9-carboxylate (1313236-77-9) + trifluoroacetic acid (76-05-1) → 1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate (1313236-80-4)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 16h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

tert-butyl 4-allyl-4-(N-((1-tosyl-1H-indol-4-yl)methyl)acrylamido)piperidine-1-carboxylate (1313236-73-5) → 1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate (1313236-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 760.05 Torr

3: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogen; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

tert-butyl 2-oxo-1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undec-3-ene-9-carboxylate (1313236-75-7) → 1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one trifluoroacetate (1313236-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 760.05 Torr

2: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane;

upstream raw materials:

tert-butyl 2-oxo-1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecane-9-carboxylate

trifluoroacetic acid

4-cyanoindole

p-toluenesulfonyl chloride

Downstream raw materials:

9-(benzo[d]oxazol-2-yl)-1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one

9-(quinoxalin-2-yl)-1-((1-tosyl-1H-indol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one

9-(4,6-dimethylpyrimidin-2-yl)-1-((1-tosyl-1Hindol-4-yl)methyl)-1,9-diazaspiro[5.5]undecan-2-one