5-[1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-3-methyl[1,2,4]oxadiazole

Base Information

Chemical Name:5-[1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-3-methyl[1,2,4]oxadiazole
CAS No.:1033575-89-1
Molecular Formula:C₂₅H₁₇Cl₃N₄O₃S
Molecular Weight:559.86
Hs Code.:

Synonyms:5-[1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-3-methyl[1,2,4]oxadiazole

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Chemical Property of 5-[1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-3-methyl[1,2,4]oxadiazole

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Technology Process of 5-[1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-3-methyl[1,2,4]oxadiazole

There total 7 articles about 5-[1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-3-methyl[1,2,4]oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1033586-98-9
C₂₃H₁₄Cl₄N₂O₃S

: 118493-85-9,117771-39-8,1141922-26-0,1429624-21-4
acetamide oxime

: 1033575-89-1
5-[1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-3-methyl[1,2,4]oxadiazole

Guidance literature:: With pyridine; In toluene; for 16h; Heating / reflux;

Reference yield:

: 1033586-53-6
N-(4-bromo-2-chlorophenyl)-2,6-dichlorobenzamidine

: 1033575-89-1
5-[1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-3-methyl[1,2,4]oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / ethanol / 2.5 h / Heating / reflux

1.2: 1 h / Heating / reflux

2.1: water; potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 2.5 h / 80 °C

3.1: sodium hydroxide; water / methanol / 2 h / 50 °C

4.1: hydrogenchloride / methanol; water; ethyl acetate

5.1: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 1.5 h / 0 - 20 °C

6.1: pyridine / toluene / 16 h / Heating / reflux

With pyridine; hydrogenchloride; sodium hydroxide; oxalyl dichloride; water; sodium hydrogencarbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N,N-dimethyl-formamide; In methanol; 1,2-dimethoxyethane; ethanol; chloroform; water; ethyl acetate; toluene; 2.1: Suzuki Coupling;

Reference yield:

: 918350-19-3
1-(4-bromo-2-chlorophenyl)-2-(2,6-dichlorophenyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 1033575-89-1
5-[1-(3-chloro-3'-methanesulfonylbiphenyl-4-yl)-2-(2,6-dichlorophenyl)-1H-imidazol-4-yl]-3-methyl[1,2,4]oxadiazole

Guidance literature:: Multi-step reaction with 5 steps

1: water; potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 2.5 h / 80 °C

2: sodium hydroxide; water / methanol / 2 h / 50 °C

3: hydrogenchloride / methanol; water; ethyl acetate

4: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 1.5 h / 0 - 20 °C

5: pyridine / toluene / 16 h / Heating / reflux

With pyridine; hydrogenchloride; sodium hydroxide; oxalyl dichloride; water; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N,N-dimethyl-formamide; In methanol; 1,2-dimethoxyethane; chloroform; water; ethyl acetate; toluene; 1: Suzuki Coupling;