(S)-N₁-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine

Base Information

• Chemical Name: (S)-N₁-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine
• CAS No.: 1438884-24-2
• Molecular Formula: C₂₄H₂₃N₇S
• Molecular Weight: 441.56

Synonyms:(S)-N₁-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine

Chemical Property of (S)-N₁-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine

Chemical Property:

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Technology Process of (S)-N₁-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine

There total 6 articles about (S)-N₁-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N1-(7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-1,2-diamine (1438883-28-3) + 1H-pyrazole-5-boronic acid (376584-63-3,1239363-47-3) → (S)-N1-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine (1438884-24-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield:

pyridine-4-carbonitrile (100-48-1) → (S)-N1-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine (1438884-24-2)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium 2,2-dimethyl-1-propanolate / 1,4-dioxane; toluene / 20 °C

2: acetic acid; bromine / chloroform / 0 - 20 °C

3: triethylamine; dmap / dichloromethane / 1 h

4: triethylamine / N,N-dimethyl acetamide / 2 h / 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol / 0.25 h / 150 °C / Microwave irradiation

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium 2,2-dimethyl-1-propanolate; sodium carbonate; acetic acid; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; chloroform; N,N-dimethyl acetamide; toluene;

Reference yield:

2,4,6-triisopropylbenzenesulfonic acid 7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl ester (1438887-46-7) → (S)-N1-[6-methyl-7-(2H-pyrazol-3-yl)-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine (1438884-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl acetamide / 2 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol / 0.25 h / 150 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In ethanol; N,N-dimethyl acetamide;

upstream raw materials:

pyridine-4-carbonitrile

6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-ol

5-methyl-3-aminothiophene-2-carboxylic acid methyl ester

7-bromo-6-methyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-ol

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