4-chloro-3-(4,6-dichloro-pyridin-3-yl)-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl benzamide

Base Information

Chemical Name:4-chloro-3-(4,6-dichloro-pyridin-3-yl)-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl benzamide
CAS No.:1070889-89-2
Molecular Formula:C₂₃H₂₂Cl₃N₃O₂
Molecular Weight:478.806
Hs Code.:

Synonyms:4-chloro-3-(4,6-dichloro-pyridin-3-yl)-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl benzamide

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Chemical Property of 4-chloro-3-(4,6-dichloro-pyridin-3-yl)-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl benzamide

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Technology Process of 4-chloro-3-(4,6-dichloro-pyridin-3-yl)-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl benzamide

There total 6 articles about 4-chloro-3-(4,6-dichloro-pyridin-3-yl)-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070893-11-6
(4,6-dichloropyridin-3-yl)boronic acid

: 1070892-30-6
3-bromo-4-chloro-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl-benzamide

: 1070889-89-2
4-chloro-3-(4,6-dichloro-pyridin-3-yl)-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl benzamide

Guidance literature:: With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; at 110 ℃;

Reference yield:

: 42860-10-6
3-bromo-4-chlorobenzoic acid

: 1070889-89-2
4-chloro-3-(4,6-dichloro-pyridin-3-yl)-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

2.1: sodium hydrogencarbonate / water; acetonitrile / 1.5 h

2.2: 16 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 80 °C

4.1: potassium fluoride / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane / 110 °C

With potassium fluoride; oxalyl dichloride; sodium hydrogencarbonate; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N-dimethyl-formamide; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 21900-34-5
3-bromo-4-chlorobenzoyl chloride

: 1070889-89-2
4-chloro-3-(4,6-dichloro-pyridin-3-yl)-N-[2-(2-dimethylamino-ethoxy)-phenyl]-N-methyl benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water; acetonitrile / 1.5 h

1.2: 16 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 80 °C

3.1: potassium fluoride / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane / 110 °C

With potassium fluoride; sodium hydrogencarbonate; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;