2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS No.: 928653-24-1
• Molecular Formula: C₄₁H₅₉NO₄Si
• Molecular Weight: 658.009

Synonyms:2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property of 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 11 articles about 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(tert-butyl-diphenyl-silanyloxymethyl)-5-formyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester → 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (928653-24-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃;

DOI:10.1016/j.bmcl.2006.10.014

Reference yield:

((E)-2-Oct-1-enyl)-benzo[1,3,2]dioxaborole (147024-83-7) → 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (928653-24-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: Pd(Ph₃P)4; NaHCO₃ / 1,2-dimethoxy-ethane / Heating

2.1: 100 percent / H₂ / Pd/C / ethyl acetate / 20 °C

3.1: Super-Hydride / tetrahydrofuran / -78 °C

3.2: PPTS / tetrahydrofuran / -78 - 20 °C

4.1: TiCl₄ / CH₂Cl₂ / -78 - 0 °C

5.1: 69 percent / Grubbs 2nd gen. cat.; N-allyltritylamine; iPr₂NEt / toluene / Heating

6.1: O₃ / CH₂Cl₂; methanol / -78 °C

6.2: Me₂S / CH₂Cl₂; methanol

7.1: NaBH₄ / methanol / 0 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-tritylprop-2-en-1-amine; hydrogen; titanium tetrachloride; lithium triethylborohydride; sodium hydrogencarbonate; ozone; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; toluene; 1.1: Suzuki coupling;

DOI:10.1016/j.bmcl.2006.10.014

Reference yield:

tert-butyl (2S,3R)-3-(4-bromophenyl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-oxopyrrolidine-1-carboxylate (928653-20-7) → 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (928653-24-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: Pd(Ph₃P)4; NaHCO₃ / 1,2-dimethoxy-ethane / Heating

2.1: 100 percent / H₂ / Pd/C / ethyl acetate / 20 °C

3.1: Super-Hydride / tetrahydrofuran / -78 °C

3.2: PPTS / tetrahydrofuran / -78 - 20 °C

4.1: TiCl₄ / CH₂Cl₂ / -78 - 0 °C

5.1: 69 percent / Grubbs 2nd gen. cat.; N-allyltritylamine; iPr₂NEt / toluene / Heating

6.1: O₃ / CH₂Cl₂; methanol / -78 °C

6.2: Me₂S / CH₂Cl₂; methanol

7.1: NaBH₄ / methanol / 0 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-tritylprop-2-en-1-amine; hydrogen; titanium tetrachloride; lithium triethylborohydride; sodium hydrogencarbonate; ozone; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; toluene; 1.1: Suzuki coupling;

DOI:10.1016/j.bmcl.2006.10.014

upstream raw materials:

((E)-2-Oct-1-enyl)-benzo[1,3,2]dioxaborole

tert-butyl (2S,3R)-3-(4-bromophenyl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-oxopyrrolidine-1-carboxylate

2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-octyl-phenyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,3R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(4-octyl-phenyl)-5-((E)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(2S,3R,5R)-2,5-Bis-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

2-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethoxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,3R,5R)-2-Hydroxymethyl-5-methoxymethoxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

5-(di-tert-butoxy-phosphoryloxymethyl)-2-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 928653-24-1 2-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-3-(4-octyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send