(S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester
CAS No.:160002-62-0
Molecular Formula:C₃₁H₃₃NO₅S
Molecular Weight:531.673
Hs Code.:

Synonyms:(S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester

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Chemical Property of (S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester

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Technology Process of (S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester

There total 3 articles about (S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: C₃₄H₃₈N₂O₈S

: 100-53-8
phenylmethanethiol

: 160002-62-0
(S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 5h;
DOI:10.1021/acs.joc.1c01949

Reference yield: 88.0%

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 100-53-8
phenylmethanethiol

: 160002-62-0
(S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 - 20 ℃;
DOI:10.1016/S0040-4039(00)77257-1

Reference yield:

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 160002-62-0
(S)-4-Benzylsulfanylcarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/acs.joc.1c01949