(R,S)-4-benzyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo[2,1-i]purin-5(4H)-one

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Chemical Name:(R,S)-4-benzyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo[2,1-i]purin-5(4H)-one
CAS No.:1313388-70-3
Molecular Formula:C₂₁H₂₃N₇O₂
Molecular Weight:405.459
Hs Code.:

Synonyms:(R,S)-4-benzyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo[2,1-i]purin-5(4H)-one

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Chemical Property of (R,S)-4-benzyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo[2,1-i]purin-5(4H)-one

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Technology Process of (R,S)-4-benzyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo[2,1-i]purin-5(4H)-one

There total 6 articles about (R,S)-4-benzyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo[2,1-i]purin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1313388-46-3
(R,S)-6-(1-hydroxybutan-2-ylamino)-3-benzyl-8-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-3H-purin-2(7H)-one

: 1313388-70-3
(R,S)-4-benzyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo[2,1-i]purin-5(4H)-one

Guidance literature:: With thionyl chloride; In dichloromethane; at 20 ℃; for 18h; Reflux;
DOI:10.1021/jm2004738

Reference yield:

: C₁₁H₈N₄O₄

: 1313388-70-3
(R,S)-4-benzyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo[2,1-i]purin-5(4H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium dithionite

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 24 h

2.3: 1.5 h

3.1: pyridine; tetraphosphorus decasulfide / 5 h / 140 °C

4.1: sodium hydroxide / ethanol / 3 h / 20 °C

5.1: dimethyl sulfoxide / 1 h / 150 °C

6.1: thionyl chloride / dichloromethane / 18 h / 20 °C / Reflux

With pyridine; thionyl chloride; sodium dithionite; tetraphosphorus decasulfide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm2004738

Reference yield:

: 1313388-97-4
3-benzyl-8-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-purine-2,6(3H,7H)-dione

: 1313388-70-3
(R,S)-4-benzyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo[2,1-i]purin-5(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; tetraphosphorus decasulfide / 5 h / 140 °C

2: sodium hydroxide / ethanol / 3 h / 20 °C

3: dimethyl sulfoxide / 1 h / 150 °C

4: thionyl chloride / dichloromethane / 18 h / 20 °C / Reflux

With pyridine; thionyl chloride; tetraphosphorus decasulfide; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm2004738