9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

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Chemical Name:9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
CAS No.:1428649-03-9
Molecular Formula:C₁₉H₁₈BrN₃OS
Molecular Weight:416.341
Hs Code.:

Synonyms:9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

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Chemical Property of 9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

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Technology Process of 9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

There total 1 articles about 9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1394235-41-6
9-bromo-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

: 2746-25-0
p-Methoxybenzyl bromide

: 1428649-03-9
9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

Guidance literature:: 9-bromo-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine; With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

p-Methoxybenzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.01.016

Reference yield: 96.0%

: 1428649-02-8
4-[(tert-butyldiphenylsilyloxy)methyl]-4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzophenone

: 1428649-03-9
9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

: 1428649-04-0
9-{4-[4-(tert-butyldiphenylsilyloxy)methyl]benzoylphenyl}-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In ethanol; water; toluene; for 1h; Reflux;
DOI:10.1016/j.bmc.2013.01.016

Reference yield:

: 1428649-03-9
9-bromo-3,4-dihydro-N-(p-methoxybenzyl)-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

: C₃₃H₂₉N₃O₃S

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / toluene; ethanol; water / 1 h / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; ethanol; water; toluene; 1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2013.01.016