Benzoic acid (1S,3R,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-bis-methoxymethoxy-2-oxo-cyclohexyl ester

Base Information

Chemical Name:Benzoic acid (1S,3R,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-bis-methoxymethoxy-2-oxo-cyclohexyl ester
CAS No.:677745-91-4
Molecular Formula:C₃₄H₄₂O₈Si
Molecular Weight:606.788
Hs Code.:

Synonyms:Benzoic acid (1S,3R,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-bis-methoxymethoxy-2-oxo-cyclohexyl ester

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Chemical Property of Benzoic acid (1S,3R,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-bis-methoxymethoxy-2-oxo-cyclohexyl ester

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Technology Process of Benzoic acid (1S,3R,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-bis-methoxymethoxy-2-oxo-cyclohexyl ester

There total 19 articles about Benzoic acid (1S,3R,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-bis-methoxymethoxy-2-oxo-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 677746-00-8
Benzoic acid (1S,2R,3S,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxy-3,4-bis-methoxymethoxy-cyclohexyl ester

: 677745-91-4
Benzoic acid (1S,3R,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-bis-methoxymethoxy-2-oxo-cyclohexyl ester

Guidance literature:: With 4 A molecular sieve; pyridinium chlorochromate; In dichloromethane; Heating;
DOI:10.1016/j.tetasy.2003.12.042

Reference yield:

: 4720-83-6
6-oxabicyclo[3.2.1]oct-3-en-7-one

: 677745-91-4
Benzoic acid (1S,3R,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-bis-methoxymethoxy-2-oxo-cyclohexyl ester

Guidance literature:: Multi-step reaction with 16 steps

1.1: 93 percent / NaHCO₃ / Heating

2.1: Novozym 435 / various solvent(s) / 20 °C

2.2: 14.5 g / lithium aluminum hydride / tetrahydrofuran / 0 °C

3.1: 14 percent / imidazole / dimethylformamide / 0 °C

4.1: mCPBA / CH₂Cl₂ / 0 °C

5.1: 98 percent / pyridine / 0 °C

6.1: 0 °C

7.1: DBU / 120 h / 80 °C

8.1: HCl / H₂O / 20 °C

9.1: NaOMe / methanol / 20 °C

10.1: 99 percent / diisopropylethylamine / CH₂Cl₂ / 40 °C

11.1: 99 percent / OsO₄; N-methylmorpholine N-oxide / acetone; H₂O / 20 °C

12.1: triethylamine; Me₂SnCl₂ / 0 °C

13.1: 94 percent / PCC; molecular sieve 4 Angstroem / CH₂Cl₂ / Heating

14.1: NaBH₄ / CH₂Cl₂; methanol / 0 °C

15.1: 83 percent / pyridine / H₂O / 100 °C

16.1: 95 percent / PCC; molecular sieve 4 Angstroem / CH₂Cl₂ / Heating

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; osmium(VIII) oxide; Novozym 435; 4 A molecular sieve; sodium methylate; dimethyltin dichloride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tetasy.2003.12.042

Reference yield:

: 4771-80-6
1,2,5,6-tetrahydrobenzoic acid

: 677745-91-4
Benzoic acid (1S,3R,4R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-bis-methoxymethoxy-2-oxo-cyclohexyl ester

Guidance literature:: Multi-step reaction with 18 steps

1.1: 93 percent / NaHCO₃; KI; I₂ / H₂O / 20 °C

2.1: 94 percent / DBU / tetrahydrofuran / Heating

3.1: 93 percent / NaHCO₃ / Heating

4.1: Novozym 435 / various solvent(s) / 20 °C

4.2: 14.5 g / lithium aluminum hydride / tetrahydrofuran / 0 °C

5.1: 14 percent / imidazole / dimethylformamide / 0 °C

6.1: mCPBA / CH₂Cl₂ / 0 °C

7.1: 98 percent / pyridine / 0 °C

8.1: 0 °C

9.1: DBU / 120 h / 80 °C

10.1: HCl / H₂O / 20 °C

11.1: NaOMe / methanol / 20 °C

12.1: 99 percent / diisopropylethylamine / CH₂Cl₂ / 40 °C

13.1: 99 percent / OsO₄; N-methylmorpholine N-oxide / acetone; H₂O / 20 °C

14.1: triethylamine; Me₂SnCl₂ / 0 °C

15.1: 94 percent / PCC; molecular sieve 4 Angstroem / CH₂Cl₂ / Heating

16.1: NaBH₄ / CH₂Cl₂; methanol / 0 °C

17.1: 83 percent / pyridine / H₂O / 100 °C

18.1: 95 percent / PCC; molecular sieve 4 Angstroem / CH₂Cl₂ / Heating

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; osmium(VIII) oxide; Novozym 435; 4 A molecular sieve; iodine; sodium methylate; dimethyltin dichloride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tetasy.2003.12.042