ethyl 6,8-dichloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)chroman-4-carboxylate

Base Information

Chemical Name:ethyl 6,8-dichloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)chroman-4-carboxylate
CAS No.:1202890-17-2
Molecular Formula:C₂₇H₂₄Cl₃NO₅
Molecular Weight:548.85
Hs Code.:

Synonyms:ethyl 6,8-dichloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)chroman-4-carboxylate

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Chemical Property of ethyl 6,8-dichloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)chroman-4-carboxylate

Chemical Property:

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Technology Process of ethyl 6,8-dichloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)chroman-4-carboxylate

There total 15 articles about ethyl 6,8-dichloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)chroman-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1233696-41-7
4-(6,8-dichloro-4-(ethoxycarbonyl)chroman-7-yloxy)benzoic acid

: 156-41-2
4-chlorophenylethylamine

: 1202890-17-2
ethyl 6,8-dichloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)chroman-4-carboxylate

Guidance literature:: 4-(6,8-dichloro-4-(ethoxycarbonyl)chroman-7-yloxy)benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.5h;

4-chlorophenylethylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling;

Reference yield:

: 74277-66-0
6-chloro-7-hydroxychroman-4-one

: 1202890-17-2
ethyl 6,8-dichloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)chroman-4-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale

1.2: 20 °C / Industry scale

2.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale

2.2: 1 h / 20 °C / Industry scale

3.1: sodium hydroxide / water / Industry scale

3.2: pH 2 - 3 / Industry scale

3.3: 16 h / Reflux

4.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere

5.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

6.1: diisobutylamine; sulfuryl dichloride / toluene / 1 h / 70 °C

7.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 4 h / 80 °C / Inert atmosphere

7.2: pH 2

8.1: ammonium chloride; zinc / tetrahydrofuran; water / 1 h / 20 °C / Inert atmosphere

9.1: nitrous acid isobutyl ester / N,N-dimethyl-formamide / 1.75 h / 70 °C

10.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

11.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

11.2: 20 °C / Cooling

With hydrogenchloride; diisobutylamine; sulfuryl dichloride; oxalyl dichloride; tin(II) chloride dihdyrate; nitrous acid isobutyl ester; water; iodine; N,N-dimethylglycine hydrochoride; potassium carbonate; ammonium chloride; caesium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; copper(l) chloride; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1202889-56-2
3-chloro-1-(5-chloro-2,4-dihydroxyphenyl)propan-1-one

: 1202890-17-2
ethyl 6,8-dichloro-7-(4-(4-chlorophenethylcarbamoyl)phenoxy)chroman-4-carboxylate

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium hydroxide / water / 10 - 20 °C / Industry scale

1.2: 1 h / 5 - 20 °C

2.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale

2.2: 20 °C / Industry scale

3.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale

3.2: 1 h / 20 °C / Industry scale

4.1: sodium hydroxide / water / Industry scale

4.2: pH 2 - 3 / Industry scale

4.3: 16 h / Reflux

5.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

7.1: diisobutylamine; sulfuryl dichloride / toluene / 1 h / 70 °C

8.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 4 h / 80 °C / Inert atmosphere

8.2: pH 2

9.1: ammonium chloride; zinc / tetrahydrofuran; water / 1 h / 20 °C / Inert atmosphere

10.1: nitrous acid isobutyl ester / N,N-dimethyl-formamide / 1.75 h / 70 °C

11.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

12.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

12.2: 20 °C / Cooling

With hydrogenchloride; diisobutylamine; sulfuryl dichloride; oxalyl dichloride; tin(II) chloride dihdyrate; nitrous acid isobutyl ester; water; iodine; N,N-dimethylglycine hydrochoride; potassium carbonate; ammonium chloride; caesium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; copper(l) chloride; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene;