N-(cyclopropylsulfonyl)-1-[(2,5-difluorophenyl)-methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-ethyl-1H-indole-2-carboxamide

Base Information

Chemical Name:N-(cyclopropylsulfonyl)-1-[(2,5-difluorophenyl)-methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-ethyl-1H-indole-2-carboxamide
CAS No.:1130318-00-1
Molecular Formula:C₂₆H₂₃F₂N₃O₄S
Molecular Weight:511.549
Hs Code.:

Synonyms:N-(cyclopropylsulfonyl)-1-[(2,5-difluorophenyl)-methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-ethyl-1H-indole-2-carboxamide

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Chemical Property of N-(cyclopropylsulfonyl)-1-[(2,5-difluorophenyl)-methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-ethyl-1H-indole-2-carboxamide

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Technology Process of N-(cyclopropylsulfonyl)-1-[(2,5-difluorophenyl)-methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-ethyl-1H-indole-2-carboxamide

There total 11 articles about N-(cyclopropylsulfonyl)-1-[(2,5-difluorophenyl)-methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-ethyl-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1130328-13-0
C₂₇H₂₅F₂N₃O₄S

: 1130318-00-1
N-(cyclopropylsulfonyl)-1-[(2,5-difluorophenyl)-methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-ethyl-1H-indole-2-carboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 90 ℃; Sealed tube; Inert atmosphere;
DOI:10.1021/jm201258k

Reference yield:

: 1130327-90-0
C₁₉H₂₀N₂O₃

: 1130318-00-1
N-(cyclopropylsulfonyl)-1-[(2,5-difluorophenyl)-methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-ethyl-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran / 70 °C / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 - 75 °C

3.2: 18 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 90 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; water; caesium carbonate; 1,1'-carbonyldiimidazole; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm201258k

Reference yield:

: 1126423-11-7
C₁₃H₁₄INO₂

: 1130318-00-1
N-(cyclopropylsulfonyl)-1-[(2,5-difluorophenyl)-methyl]-3-(1,2-dihydro-2-oxo-3-pyridinyl)-5-ethyl-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate / 1,2-dimethoxyethane; water / 4 h / 20 - 90 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran / 70 °C / Inert atmosphere

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 20 - 75 °C

4.2: 18 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 90 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; potassium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1021/jm201258k