(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-((triethylsilyl)ethynyl)phenyl)ethyl)-1,3-oxazinan-2-one

Base Information

Chemical Name:(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-((triethylsilyl)ethynyl)phenyl)ethyl)-1,3-oxazinan-2-one
CAS No.:1259034-67-7
Molecular Formula:C₃₀H₄₁NO₃Si
Molecular Weight:491.746
Hs Code.:

Synonyms:(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-((triethylsilyl)ethynyl)phenyl)ethyl)-1,3-oxazinan-2-one

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Chemical Property of (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-((triethylsilyl)ethynyl)phenyl)ethyl)-1,3-oxazinan-2-one

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Technology Process of (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-((triethylsilyl)ethynyl)phenyl)ethyl)-1,3-oxazinan-2-one

There total 9 articles about (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-((triethylsilyl)ethynyl)phenyl)ethyl)-1,3-oxazinan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1777-03-3
2-triethylsilylacetylene

: 1110641-70-7
(S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one

: 1259034-67-7
(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-((triethylsilyl)ethynyl)phenyl)ethyl)-1,3-oxazinan-2-one

Guidance literature:: With copper(l) iodide; triethylamine; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Irradiation;

Reference yield:

: 27298-97-1
(S)-1-(4-bromophenyl)ethylamine

: 1259034-67-7
(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-((triethylsilyl)ethynyl)phenyl)ethyl)-1,3-oxazinan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 2 - 3 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / Reflux

3.1: copper(l) chloride; oxygen / palladium dichloride / N,N-dimethyl-formamide; water / 20 °C

4.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: Cooling with ice

5.1: triethylamine; triphenylphosphine; copper(l) iodide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 0.5 h / 120 °C / Irradiation

With copper(l) iodide; oxygen; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; copper(l) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 936-59-4
3-chloropropiophenone

: 1259034-67-7
(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-((triethylsilyl)ethynyl)phenyl)ethyl)-1,3-oxazinan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc; ammonium chloride / water; tetrahydrofuran / 1 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / Reflux

3.1: copper(l) chloride; oxygen / palladium dichloride / N,N-dimethyl-formamide; water / 20 °C

4.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: Cooling with ice

5.1: triethylamine; triphenylphosphine; copper(l) iodide / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 0.5 h / 120 °C / Irradiation

With copper(l) iodide; oxygen; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; copper(l) chloride; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;