6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methylamide

Base Information

Chemical Name:6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methylamide
CAS No.:1617517-28-8
Molecular Formula:C₂₂H₂₃N₃O₅S
Molecular Weight:441.508
Hs Code.:

Synonyms:6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methylamide

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Chemical Property of 6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methylamide

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Technology Process of 6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methylamide

There total 12 articles about 6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.62%

: methylamine hydrochloride salt

: 1617516-85-4
6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid

: 1617517-28-8
6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methylamide

Guidance literature:: 6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.5h;

methylamine hydrochloride salt; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 7559-81-1,54839-86-0
chlorokojic acid

: 1617517-28-8
6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium azide / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: sodium hydroxide / methanol / 1 h / 20 °C

3.1: triphenylphosphine; water / tetrahydrofuran / 16 h / Reflux

4.1: pyridine / dichloromethane / 16 h / 20 °C / Cooling with ice

5.1: sulfuric acid / acetic acid / 24 h / 80 °C

6.1: sodium hydroxide; water / 1,4-dioxane / 6 h / 20 °C

7.1: sodium hydroxide / methanol; water / 24 h / Reflux

8.1: 2-iodoxybenzoic acid / ethyl acetate / 6 h / 60 °C

9.1: sodium chlorite; aminosulfonic acid / water; acetone / 16 h / 20 °C

10.1: methanol / 6 h / 20 °C

11.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

11.2: 16 h / 20 °C

With pyridine; sodium chlorite; sodium azide; 2-iodoxybenzoic acid; sulfuric acid; aminosulfonic acid; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1617516-81-0
N-(5-hydroxy-6-hydroxymethyl-4-oxo-4H-pyran-2-ylmethyl)-benzene sulfonamide

: 1617517-28-8
6-(benzenesulfonylamino-methyl)-3-benzyloxy-1-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / methanol; water / 24 h / Reflux

2.1: 2-iodoxybenzoic acid / ethyl acetate / 6 h / 60 °C

3.1: sodium chlorite; aminosulfonic acid / water; acetone / 16 h / 20 °C

4.1: methanol / 6 h / 20 °C

5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

5.2: 16 h / 20 °C

With sodium chlorite; 2-iodoxybenzoic acid; aminosulfonic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone;