5-mesityl-1-(3,4,5-trimethoxyphenyl)-4-(trimethylsilyl)-1H-1,2,3-triazole

Base Information

Chemical Name:5-mesityl-1-(3,4,5-trimethoxyphenyl)-4-(trimethylsilyl)-1H-1,2,3-triazole
CAS No.:1338916-54-3
Molecular Formula:C₂₃H₃₁N₃O₃Si
Molecular Weight:425.603
Hs Code.:

Synonyms:5-mesityl-1-(3,4,5-trimethoxyphenyl)-4-(trimethylsilyl)-1H-1,2,3-triazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-mesityl-1-(3,4,5-trimethoxyphenyl)-4-(trimethylsilyl)-1H-1,2,3-triazole

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Technology Process of 5-mesityl-1-(3,4,5-trimethoxyphenyl)-4-(trimethylsilyl)-1H-1,2,3-triazole

There total 4 articles about 5-mesityl-1-(3,4,5-trimethoxyphenyl)-4-(trimethylsilyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1,3,5-trimethyl-2-[(2-trimethylsilyl)ethynyl]benzene

: 115483-29-9
3,4,5-trimethoxyphenyl azide

: 1338916-54-3
5-mesityl-1-(3,4,5-trimethoxyphenyl)-4-(trimethylsilyl)-1H-1,2,3-triazole

Guidance literature:: In water; at 110 ℃; for 17h; regioselective reaction;
DOI:10.1002/asia.201100404

Reference yield:

: 88-05-1
2,4,6-trimethylaniline

: 1338916-54-3
5-mesityl-1-(3,4,5-trimethoxyphenyl)-4-(trimethylsilyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / Cooling with ice

1.2: 0.83 h / -5 °C

1.3: 76 h / 20 °C

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / tetrahydrofuran / 17 h / 50 °C / Inert atmosphere

3.1: water / 17 h / 110 °C

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; In tetrahydrofuran; water; 2.1: Sonogashira coupling;
DOI:10.1002/asia.201100404

Reference yield:

: 24313-88-0
3,4,5-Trimethoxyaniline

: 1338916-54-3
5-mesityl-1-(3,4,5-trimethoxyphenyl)-4-(trimethylsilyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water; sodium nitrite / 1 h / 0 °C / 760.05 Torr

1.2: 0.17 h / 0 °C

2.1: water / 17 h / 110 °C

With hydrogenchloride; water; sodium nitrite; In water;
DOI:10.1002/asia.201100404