1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester

Base Information

Chemical Name:1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester
CAS No.:952019-78-2
Molecular Formula:C₂₃H₂₁Cl₂NO₄
Molecular Weight:446.33
Hs Code.:

Synonyms:1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester

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Chemical Property of 1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester

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Technology Process of 1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester

There total 5 articles about 1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 952019-74-8
1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester

: 952019-78-2
1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester

Guidance literature:: With sodium hydroxide; In ethanol;
DOI:10.1080/00397910701481237

Reference yield:

: 952019-72-6
2-acetyl-3-(4-chlorobenzoyl)succinic acid 4-tert-butyl ester 1-ethyl ester

: 952019-78-2
1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 36 percent / AcOH / 24 h / Heating

2: 75 percent / aq. NaOH / ethanol

With sodium hydroxide; acetic acid; In ethanol; 1: Paal-Knorr cyclization;
DOI:10.1080/00397910701481237

Reference yield:

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

: 952019-78-2
1-(2-chlorophenyl)-2-(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

1.2: 100 percent / tetrahydrofuran / 4 h / -78 - 20 °C

2.1: EtONa / ethanol / 0.17 h

2.2: 19 percent / ethanol; toluene / 7 h / 20 °C

3.1: 36 percent / AcOH / 24 h / Heating

4.1: 75 percent / aq. NaOH / ethanol

With sodium hydroxide; sodium ethanolate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; 3.1: Paal-Knorr cyclization;
DOI:10.1080/00397910701481237