3-(tert-butyldimethylsilyloxy)-1-[4-(3,4-dichloro benzyloxy)phenyl]propan-1-ol

Base Information

Chemical Name:3-(tert-butyldimethylsilyloxy)-1-[4-(3,4-dichloro benzyloxy)phenyl]propan-1-ol
CAS No.:1202577-14-7
Molecular Formula:C₂₂H₃₀Cl₂O₃Si
Molecular Weight:441.47
Hs Code.:

Synonyms:3-(tert-butyldimethylsilyloxy)-1-[4-(3,4-dichloro benzyloxy)phenyl]propan-1-ol

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Chemical Property of 3-(tert-butyldimethylsilyloxy)-1-[4-(3,4-dichloro benzyloxy)phenyl]propan-1-ol

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Technology Process of 3-(tert-butyldimethylsilyloxy)-1-[4-(3,4-dichloro benzyloxy)phenyl]propan-1-ol

There total 3 articles about 3-(tert-butyldimethylsilyloxy)-1-[4-(3,4-dichloro benzyloxy)phenyl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 889071-55-0
(27A) 4-[(4-Bromophenoxy)methyl]-1,2-dichlorobenzene

: 89922-82-7
3-(tert-butyldimethylsilanyloxy)propionaldehyde

: 1202577-14-7
3-(tert-butyldimethylsilyloxy)-1-[4-(3,4-dichloro benzyloxy)phenyl]propan-1-ol

Guidance literature:: (27A) 4-[(4-Bromophenoxy)methyl]-1,2-dichlorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

3-(tert-butyldimethylsilanyloxy)propionaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1202577-14-7
3-(tert-butyldimethylsilyloxy)-1-[4-(3,4-dichloro benzyloxy)phenyl]propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 0.08 h / -78 °C

With n-butyllithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; toluene;

Reference yield:

: 1805-32-9
3,4-dichlorobenzyl alcohol

: 1202577-14-7
3-(tert-butyldimethylsilyloxy)-1-[4-(3,4-dichloro benzyloxy)phenyl]propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 0.08 h / -78 °C

With n-butyllithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; toluene;