methyl (Z)-2-(benzyloxycarbonylamino)-3-[4-bis(tert-butoxycarbonyl)methyl]naphthylacrylate

Base Information

Chemical Name:methyl (Z)-2-(benzyloxycarbonylamino)-3-[4-bis(tert-butoxycarbonyl)methyl]naphthylacrylate
CAS No.:901273-07-2
Molecular Formula:C₃₃H₃₇NO₈
Molecular Weight:575.659
Hs Code.:

Synonyms:methyl (Z)-2-(benzyloxycarbonylamino)-3-[4-bis(tert-butoxycarbonyl)methyl]naphthylacrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (Z)-2-(benzyloxycarbonylamino)-3-[4-bis(tert-butoxycarbonyl)methyl]naphthylacrylate

Chemical Property:

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Technology Process of methyl (Z)-2-(benzyloxycarbonylamino)-3-[4-bis(tert-butoxycarbonyl)methyl]naphthylacrylate

There total 1 articles about methyl (Z)-2-(benzyloxycarbonylamino)-3-[4-bis(tert-butoxycarbonyl)methyl]naphthylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 901273-04-9
di-tert-butyl 2-(4-formylnaphthyl)malonate

: 100945-15-1,88568-95-0
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 901273-07-2
methyl (Z)-2-(benzyloxycarbonylamino)-3-[4-bis(tert-butoxycarbonyl)methyl]naphthylacrylate

Guidance literature:: With 1,1,3,3-tetramethylguanidine; In tetrahydrofuran; at -78 - 20 ℃; for 7h;
DOI:10.1002/ejoc.200500835

Reference yield:

: 901273-07-2
methyl (Z)-2-(benzyloxycarbonylamino)-3-[4-bis(tert-butoxycarbonyl)methyl]naphthylacrylate

: 901273-14-1
N-(benzyloxycarbonyl)-β-{1-[4-bis(tert-butoxycarbonyl)methyl]naphthyl}-L-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / H₂; bis(1,5-cyclooctadiene)rhodium trifluoromethanesulfonate; (S,S)-Me-DuPHOS / methanol / 24 h / 7600 Torr

2: 85 percent / aq. Na₂CO₃ / methanol / 16 h / 20 °C

With bis(cycloocta-1,5-diene)rhodium(I) trifluoromethanesulfonate; hydrogen; sodium carbonate; 1,2-bis((2S,5S)-2,5-dimethylphospholano)benzene; In methanol;
DOI:10.1002/ejoc.200500835

Reference yield:

: 901273-07-2
methyl (Z)-2-(benzyloxycarbonylamino)-3-[4-bis(tert-butoxycarbonyl)methyl]naphthylacrylate

: N-(benzyloxycarbonyl)-β-[1-(4-malonyl)naphthyl]-L-alanine

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / H₂; bis(1,5-cyclooctadiene)rhodium trifluoromethanesulfonate; (S,S)-Me-DuPHOS / methanol / 24 h / 7600 Torr

2: 85 percent / aq. Na₂CO₃ / methanol / 16 h / 20 °C

3: 95 percent / TFA / CH₂Cl₂ / 2.5 h / 0 - 20 °C

With bis(cycloocta-1,5-diene)rhodium(I) trifluoromethanesulfonate; hydrogen; sodium carbonate; 1,2-bis((2S,5S)-2,5-dimethylphospholano)benzene; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1002/ejoc.200500835