(S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-aminopropanoic acid methyl ester

Base Information

• Chemical Name: (S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-aminopropanoic acid methyl ester
• CAS No.: 1213850-58-8
• Molecular Formula: C₁₂H₁₁F₆NO₂
• Molecular Weight: 315.215

Synonyms:(S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-aminopropanoic acid methyl ester

Chemical Property of (S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-aminopropanoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-aminopropanoic acid methyl ester

There total 3 articles about (S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-aminopropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

→ (S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-aminopropanoic acid methyl ester (1213850-58-8)

Guidance literature:

With methanol; ethylenediamine; at 70 ℃; for 5h;

Reference yield: 75.8%

methyl (S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)propanoate → (S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-aminopropanoic acid methyl ester (1213850-58-8)

Guidance literature:

With ethylenediamine; In methanol; at 70 ℃; for 9h; Reflux;

DOI:10.1016/j.bmc.2016.04.025

Reference yield:

(S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)propanamide → (S)-3-(3,5-bis(trifluoromethyl)phenyl)-2-aminopropanoic acid methyl ester (1213850-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / 25 h / 100 °C / Sealed tube

2: ethylenediamine / methanol / 9 h / 70 °C / Reflux

With boron trifluoride diethyl etherate; ethylenediamine; In methanol;

DOI:10.1016/j.bmc.2016.04.025

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