3-allyl-6-chloro-7,8-dimethoxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

• Chemical Name: 3-allyl-6-chloro-7,8-dimethoxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
• CAS No.: 765218-10-8
• Molecular Formula: C₂₂H₂₆ClNO₂
• Molecular Weight: 371.907

Synonyms:3-allyl-6-chloro-7,8-dimethoxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property of 3-allyl-6-chloro-7,8-dimethoxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property:

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Technology Process of 3-allyl-6-chloro-7,8-dimethoxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 5 articles about 3-allyl-6-chloro-7,8-dimethoxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

6-Chloro-7,8-dimethoxy-1-m-tolyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine (781561-80-6) + allyl bromide (106-95-6) → 3-allyl-6-chloro-7,8-dimethoxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (765218-10-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 2h;

DOI:10.1021/jm00346a005

Reference yield:

3-methylstyrene oxide (704898-29-3,1195902-12-5,20697-03-4) → 3-allyl-6-chloro-7,8-dimethoxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (765218-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 18 h / 110 °C

2: H₂SO₄, CF₃COOH / 2 h / Heating

3: 66 percent / K₂CO₃ / dimethylformamide / 2 h / 120 °C

With sulfuric acid; potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00346a005

Reference yield:

2-(2-chloro-3,4-dimethoxyphenyl)ethylamine (67287-36-9) → 3-allyl-6-chloro-7,8-dimethoxy-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (765218-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 18 h / 110 °C

2: H₂SO₄, CF₃COOH / 2 h / Heating

3: 66 percent / K₂CO₃ / dimethylformamide / 2 h / 120 °C

With sulfuric acid; potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00346a005

upstream raw materials:

6-Chloro-7,8-dimethoxy-1-m-tolyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

allyl bromide

3-methylstyrene oxide

2-(2-chloro-3,4-dimethoxyphenyl)ethylamine

Downstream raw materials:

SKF₈₃₈₂₂ hydrobromide

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