(R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester

Base Information

Chemical Name:(R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester
CAS No.:1449137-74-9
Molecular Formula:C₂₆H₃₃N₃O₅
Molecular Weight:467.565
Hs Code.:

Synonyms:(R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester

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Chemical Property of (R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester

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Technology Process of (R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester

There total 9 articles about (R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1449137-75-0
(R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid

: 67-63-0,8013-70-5
isopropyl alcohol

: 1449137-74-9
(R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester

Guidance literature:: With hydrogenchloride; In water; Reflux;

Reference yield:

: 1449137-73-8
(R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid methyl ester

: 1449137-74-9
(R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / tetrahydrofuran / 3 h / Reflux

2: hydrogenchloride / water / Reflux

With hydrogenchloride; water; sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 1449136-92-8
6-(2,2,2-trichloroacetyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenylpropyl)amide

: 1449137-74-9
(R)-1-[8-((R)-1-phenylpropylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]pyrrolidine-2-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / tetrahydrofuran / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.75 h / 25 °C

2.2: 25 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 3 h / Reflux

4.1: hydrogenchloride / water / Reflux

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;